[Oncolytic viruses as a new way of treatment of neoplastic diseases].

Despite the unceasing progression in chemotherapy, radiotherapy and surgery, neoplasms are still the second, after cardiovascular diseases, cause of death in the world. The creation of oncolytic viruses gives hope for increase of anticancer therapy effectiveness. Oncolytic viruses are the type of viruses that selectively infect and cause the lyse of tumor cells excluding normal cells.

[Mental disorders in digestive system diseases - internist's and psychiatrist's insight].

Mental disorders accompanying digestive system diseases constitute interdisciplinary yet scarcely acknowledged both diagnostic and therapeutic problem. One of the mostly recognized examples is coeliac disease where patients endure the large spectrum of psychopathological symptoms, starting with attention deficit all the way down to the intellectual disability in extreme cases. It has not been fully explained how the pathomechanism of digestive system diseases affects patient's mental health, however one of the hypothesis suggests that it is due to serotonergic or opioid neurotransmission imbalance caused by gluten and gluten metabolites effect on central nervous system.

[Antiangiogenic therapy of malignant pheochromocytoma and paraganglioma with the view to the recent scientific developments].

Pheochromocytoma is a very rare tumor that stems from chromaffin cells and usually develops in the adrenal glands. Its equivalent, which exists outside of the adrenal glands, is paraganglioma. Approximately 10-26% of pheochromocytoma is malignant, what poses a significant therapeutical problem, as its presence, together with an abundant production of catecholamines, may lead to a number of perilous complications, such as spinal cord oppression or the damage of organs, what is responsible for producing catecholamines.

[Hyperthermic intraperitoneal chemotherapy as a new way of peritoneal metastases treatment].

Peritoneal neoplastic disease may originate primarily from neoplasms developing in peritoneum or metastases of cancers mostly arising in digestive or female reproductive systems. Peritoneal neoplasia leads to a much poorer prognosis and in most cases the palliative care, which focus on gastrointestinal motility and patency, adequate analgesia and psychological care, is being introduced. Systemic chemotherapy is ineffective as a result of existence of physiological blood-peritoneal barrier that blocks hydrophilic chemotherapeutics.

[Safety of bariatric surgery in women of childbearing age and its future impact on their offspring].

Obesity is the greatest epidemic of the 21st century. Unfortunately, it is more and more common among young people, including women in reproductive age who may suffer from difficulties with conceiving, pregnancy complications and increased maternal-fetal risk in the perinatal period. As a result of poor effectiveness of conservative treatment of obesity, a new trend has emerged to use surgical methods, which show positive effects on patients'fertility.

[Radioiodine--today's trends in treatment of benign thyroid diseases].

Radioiodine therapy is a highly recognizable method of treatment of benign thyroid diseases. The therapy gains a widespread interest of research groups, which find it as a promising weapon against endocrine disorders caused by benign thyroid diseases. According to the latest scientific research, factors, previously thought to be impossible to modify (intra-individual variation in radiosensitivity), has become modifiable.