α,β-DIBROMOCHALCONE DERIVATIVES--SYNTHESIS AND ANTIMICROBIAL ACTIVITY.

Aim: To obtain some chalcones and their dibrominated analogues and to evaluate their antimicrobial potential.

Material And Methods: Eight chalcones were synthesized using the Claisen-Schmidt condensation of acetophenone/4-bromo-acetophenone and different benzaldehyde derivatives. These chalcones were further brominated using two different bromination agents: molecular bromine and pyridinium tribromide.

Phytotoxicity assessment of methanolic extracts from Coriadrum sativum L. fruits.

Unlabelled: The fruits of Coriandrum sativum L. (Apiaceae) are used as a spicing and flavoring agent in food products and are also recommended as a drug in the treatment of digestive tract disorders. The safety of botanicals and botanical preparations used as food supplements is of great interest, as the market of such products is expanding worldwide.

[Contributions to the chemical study of the essential oil isolated from coriander fruits (Sandra cultivar)].

Unlabelled: Coriandrum sativum L. (Apiaceae) is a well known herb, native to the Mediterranean region, also intensively cultivated in Romania. The essential oil obtained from Coriandri fructus posseses antimicrobial, antioxidant and anxiolytic effects.

[Antimicrobial activity of some cinnamic acid derivatives].

Due to drug-resistance phenomenon, there is a constant need for discovering new antiinfectious agents. A series of cinnamic acid derivatives was synthesized and then brominated with bromine in the presence of chloroform or acetic acid. The structure of the new compounds was confirmed by elemental and spectral data.

[Chemical composition of essential oil obtained from Romanian fennel fruits].

Unlabelled: For therapeutical purposes, fennel (Foeniculum vulgare Mill.), an important aromatic plant, is used for its expectorant, antispasmodic, carminative and diuretic properties. The chemical composition, especially of the volatile fraction, depends on the origin of the plant, and the ecological and environmental conditions in which it grows.

[Studies regarding chemical composition of lavender volatile oils].

Aim: In this paper, we studied comparatively volatile fractions obtained by hydrodistillation from 5 samples of lavender flowers (L. angustifolia ssp. angustifolia, L.

[Histo-anatomical researches of two subspecies of Lavandula angustifolia Mill].

Aim: The structure of the inflorescences of two subspecies of Lavandula angustifolia sL. angustifolia ssp. angustifolia and.

[Contributions to the study of the chemical variability of some Galium album Mill. Populations harvested from wild flora in northern Moldavia].

Unlabelled: Within a complex research regarding the chemical intra- and inter-specific variability of some medicinal plants, we compared two species of Galium: Galium verum L. and Galium album Mill.

Aim: In the present study, we quantified some secondary metabolites from 7 natural populations of Galium album Mill.

[Contributions to the comparative study of the antioxidant potential of some extracts obtained from chamomile flowers].

Unlabelled: Within a complex research regarding the pharmaceutical quality of Chamomillae flos commercialized in the Romanian pharmaceutical network (as well as the food chain), we investigated 9 samples of chamomile "tea" purchased in April/May 2005 in compliance to the European Pharmacopoeia.

Aim: Since the vegetal material proved to be very different from the chemical composition point of view we tried to establish the antioxidant activity of some extracts (tinctures and infusions) obtained from the selected plant material.

Material And Methods: Therefore we studied the scavenging abilities observed against DPPH and the ferrous binding propreties correlating its to the polyphenolic content previously determined in the chamomile extracts.

[Contribution to the phytochemical study of polyphenols in ten hydroalcoholic extracts of Chamomile floss].

Unlabelled: Continuing a series of studies that intend to evaluate the pharmaceutical quality of 10 commercial samples of chamomile, we tried to investigate the chemical composition of the hydroalcoholic extracts obtained in our laboratory, starting from this raw material.

Material And Method: The qualitative and semiquantitative analysis of the extracts was done by HPLC means.

Results: All extractive solutions have a high content in ferulic acid, whereas the caffeic acid level is the lowest.

[Microbiological evaluation of some commercial brands of Chamomillae floss].

Unlabelled: Different strains of microorganisms contaminate medicinal herb, and theirs, enzymes could modify the normal composition of herbal products.

Material And Methods: We evaluated the microbiological quality of 12 samples of Chamomillae floss commercialized in, markets and specific stores. Microbiological quality has been evaluated according European Pharmacopoeia rules.

Characterization of some extractive fractions isolated from raw Allium cepa L. bulbs.

Unlabelled: Many recent studies have showed that onion (Allium cepa L.) has antioxidant effect which could be of great importance for prevention and treatment of different diseases: diabetes, cancer, cardiovascular and neurodegenerative disorders. The aim of this study was to investigate the antioxidant capacity of two extracts isolated from fresh onion bulbs: an hydroalcoholic extract (codified EC1) and an aqueous extract (codified EC2).

[The antistress effect of the saponinic summ extracted from roots of Aralia mandshurica cultivated in Moldavia].

Unlabelled: The effects of the saponinic summ extracted from roots of Aralia mandshurica have been studied in experimentally animals exposed to stress.

Material And Methods: The experiment was carried out on 4 groups of animals divided into 24 lots of 12 white rats each with experimentally induced chronic inflammation or/and exposed to stress induced by exposure to continuous dark or light. The drugs (Levamisole (LVM) (10mg/kg bw/day), Indometacin (IND) (1.

Chemical composition and in vitro antimicrobial activity of essential oil of Melissa officinalis L. from Romania.

Unlabelled: Melissa officinalis L. (lemon balm) is used in traditional medicine to treat insomnia, anxiety, gastric conditions, psychiatric conditions, migraines, hypertension and bronchial conditions. Natural essential oils (mixtures of fragrant chemical) obtained from various parts of plants are efficient active antimicrobial agents.

In vitro antimicrobial activity and chemical composition of the essential oil of Foeniculum vulgare Mill.

Unlabelled: In our study, four samples of volatile oil from Foeniculum vulgare, cultivated in different pedoclimatic conditions, were investigated for their antimicrobial activity and chemical composition.

Material And Methods: Organisms. Staphylococcus aureus ATCC 25923, Bacillus cereus, Pseudomonas aeruginosa, Escherichia coli ATCC 25922, Candida albicans were included in the report.

Polysaccharides fraction isolated from ginkgo biloba folium: immunopharmacological properties.

Unlabelled: Many macromolecular compounds of vegetal polysaccharides type develop important immunostimulatory properties.

Materials And Methods: Crude macromolecular fraction was isolated from the leaves of Ginkgo biloba L. (codified as PGfol) harvested from Botanical Gardens of Iaşi, Romania.

[Contributions to chemical study of the raw polysaccharide isolated from the fresh pressed juice of white cabbage leaves].

In traditional medicine fresh pressed juice of white cabbage leaves is used in the treatment of many diseases in which immunity disorders are involved: diabetes mellitus, rheumatism, gastric ulcer, cirrhosis, cancer. The efficiency of fresh cabbage juice might be due to an immunomodulatory activity. Polysaccharides are hydrosoluble compounds for which there have been pointed out immunomodulatory effects in recent years.

[Study on the antioxidant activity of Menthae longifoliae folium and effect of pesticide treatment with Topsin M on the antioxidant activity].

This study evaluated both the antioxidant activity of Menthae longifoliae folium and the influence of Topsin M (a pesticide which is widely used nowadays) upon the antioxidant activity of the drug. In this respect, there have been used leaves of Mentha longifolia (L.) Huds.

[Phytochemical investigations regarding the flavonoidic compounds of some species belonging to the Achillea millefolium L. group].

In this study a qualitative and quantitative analysis of flavonoids from flower heads of Achillea species belonging to the A. millefolium L. group was achieved.

[The experimental evaluation regarding analgesic activity of some extracts isolated from Achillea collina J. Becker ex Reichenb].

In the present investigation we have evaluated the potential existence of analgesic activity of the residue of tincture and of the crude lipophilic (AC 2, AC 4) and hydrophilic portions (AC 1, AC 3) of infusion and decoction obtained from flower heads of Achillea collina J. Becker ex Reichenb. Acid acetic induced writhing and vascular permeability test was performed by the method of Whittle.

[Pharmacognostic research of some species of Achillea. Note 1. Volatile oils analysis].

We established the hydrodistilled essential oil yields from the dried flower heads of A. collina J. Becker ex Reichenb.