Publications by authors named "Ursula Schulte-Overberg"
Twenty-two children with immune thrombocytopenic purpura (ITP) with long-lasting thrombocytopenia, adversely affecting their quality of life, were treated with a reduced rituximab regimen in order to eliminate B cells producing anti-platelet antibody. A single dose of rituximab resulted in a response rate similar to that reported for cases in which 4 doses of rituximab were used.
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- Mutations in the LMAN1 gene lead to a bleeding disorder known as F5F8D, which features low levels of clotting factors V and VIII due to problems with their secretion from cells.
- LMAN1 is a protein that helps package secreted proteins; defects in it may interfere with normal protein export in the body.
- Research also identifies mutations in another gene, MCFD2, that produce similar bleeding issues, suggesting that both LMAN1 and MCFD2 work together as specific cargo receptors in transporting critical proteins within the cell.
The purpose of the study was to evaluate transcranial Doppler ultrasonography for identifying cerebrovascular disease in neurologically asymptomatic children and young adults with sickle cell disease. A total of 47 consecutive patients with sickle cell disease (28 females, 19 males; age range 8 months to 29 years, mean age 9 years 6 months) were evaluated by transcranial color and duplex Doppler ultrasonography via transtemporal and occipital (2-MHz probe) as well as by transocular (5-MHz probe) approach. Eleven vessels (middle, posterior, anterior cerebral artery, vertebral artery, ophthalmic artery on each side and basilar artery) were analyzed in each patient.
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