Publications by authors named "Ursula Koehler"
Abdominal pain, cramping, and discomfort (APCD) are experienced by up to 30 % of adults in Europe. To assess the impact of APCD on quality of life (QoL) and to investigate the effectiveness, tolerability, and impact on QoL of hyoscine butylbromide (HBB, Buscopan) compared with STW 5 (Iberogast) or analgesics in women with APCD. An internet-based observational pilot study was conducted in Germany in women who had predominantly used HBB, STW 5, or analgesics (n = 240 per treatment) to treat APCD.
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- Btk is an important protein in immune cells, and inhibiting it shows promise for treating autoimmune diseases, especially lupus.
- In mouse models of lupus, the Btk inhibitor M7583 was effective in reducing symptoms and mortality, but not all effects were uniform across different models.
- The study suggests that blocking Btk can reduce inflammation linked to immune complex activation, offering potential benefits for patients with systemic lupus erythematosus (SLE) by targeting different immune pathways.
Objectives: Although it has been used as a laxative for many years, high-quality trials assessing the efficacy of the laxative sodium picosulfate (SPS) are lacking. The purpose of this study was to assess the efficacy and safety of 4-week treatment with SPS in patients with functional constipation as defined by the Rome III diagnostic criteria.
Methods: This study was a randomized, double-blind, placebo-controlled, parallel-group study in 45 general practices in Germany.