Publications by authors named "Ursula Houessou"
Background And Aims: Estimating the genetic risk of coronary artery disease (CAD) is now possible by aggregating data from genome-wide association studies (GWAS) into polygenic risk scores (PRS). Combining multiple PRS for specific circulating blood lipids could improve risk prediction. Here, we sought to evaluate the performance of PRS derived from CAD and blood lipids GWAS to predict the incidence of CAD.
View Article and Find Full Text PDFThere is currently no medical therapy to prevent calcific aortic valve stenosis (CAVS). Multi-omics approaches could lead to the identification of novel molecular targets. Here, we perform a genome-wide association study (GWAS) meta-analysis including 14,819 cases among 941,863 participants of European ancestry.
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- Researchers are exploring therapies targeting ANGPTL3 to lower lipoprotein-lipid levels and reduce the risk of cardiovascular diseases.
- The study employed Mendelian randomisation to assess how genetic variations affect ANGPTL3 expression and their potential impact on triglyceride and apoB levels, as well as various heart-related conditions.
- Results showed that common genetic variants significantly lowered plasma triglyceride levels, while having minimal effects on LDL cholesterol and no impact on coronary artery disease or other cardiometabolic diseases.
Article Synopsis
- Mutations in the PQBP1 gene are linked to Renpenning syndrome, a neurodevelopmental disorder that causes intellectual disability, primarily affecting males due to its X-linked inheritance.
- Researchers knocked down PQBP1 in human neural stem cells, finding reduced cell growth and changes in 58 gene expressions related to neurodegeneration and immunity.
- The study identified a specific isoform of the UPF3B gene associated with PQBP1 mutations, suggesting unique functions for different isoforms, and utilized this finding to assess the impact of various PQBP1 gene variants in patients with neurodevelopmental disorders.