Pharmacokinetics and Changes in Lipid Mediator Profiling after Consumption of Specialized Pro-Resolving Lipid-Mediator-Enriched Marine Oil in Healthy Subjects.

Omega-3 polyunsaturated fatty acids (PUFAs) play a vital role in human health, well-being, and the management of inflammatory diseases. Insufficient intake of omega-3 is linked to disease development. Specialized pro-resolving mediators (SPMs) are derived from omega-3 PUFAs and expedite the resolution of inflammation.

New Pt→M (M = Ag or Tl) complexes based on anionic cyclometalated Pt(ii) complexes.

Anionic cyclometalated complexes (NBu)[Pt(CNC)X] (X = Cl (1), CN (2), or S-2py (pyridine-2-thiolate) (3); -CNC- = 2,6-di(phen-2-ide)-pyridine) have been used as precursors in the synthesis of heteropolynuclear Pt-Ag or Pt-Tl complexes containing donor-acceptor metal-metal bonds. Their reaction with AgClO or [Ag(OClO)(PPh)] produces complexes in which the nuclearity and structure seem to be determined by the ability of the ligand X to form bridges between the metals. Thus, the characteristic linear bridging of the cyano ligand leads to the formation of an octanuclear [{Pt(CNC)(μ-CN)}Ag] (4) or tetranuclear [{Pt(CNC)(μ-CN)}{Ag(PPh)}] (6) complex, with CN bridges between different "Pt-Ag" units.

Pt-M Complexes (M=Ag, Au) as Models for Intermediates in Transmetalation Processes.

Heteropolynuclear complexes [(CNC)(PPh )PtM(PPh )]ClO [M=Au (1), Ag (2)] and [{Pt(CNC)(PPh )} M]ClO [M=Ag (3), Au (4); CNC=2,6-diphenylpyridinate] were prepared and studied by X-ray crystallography, spectroscopic techniques, and DFT calculations. The X-ray crystal structures of 1, 3, and 4 confirmed the existence of Pt-M bonds and M⋅⋅⋅C interactions involving one of the phenyl fragments of CNC. Their NMR spectra showed the persistence of the Pt-M interactions in solution and also revealed an intramolecular metronome-like dynamic process consisting of back-and-forth motion of the acidic M fragments along the C-Pt-C axis.

Correction: Preparation of Pt-Tl clusters showing new geometries. X-ray, NMR and luminescence studies.

Correction for 'Preparation of Pt-Tl clusters showing new geometries. X-ray, NMR and luminescence studies by Úrsula Belío et al., Dalton Trans.

Unusual Metal-Metal Bonding in a Dinuclear Pt-Au Complex: Snapshot of a Transmetalation Process.

The dinuclear Pt-Au complex [(CNC)(PPh3 )Pt Au(PPh3 )](ClO4 ) (2) (CNC=2,6-diphenylpyridinate) was prepared. Its crystal structure shows a rare metal-metal bonding situation, with very short Pt-Au and Au-Cipso (CNC) distances and dissimilar Pt-Cipso (CNC) bonds. Multinuclear NMR spectra of 2 show the persistence of the Pt-Au bond in solution and the occurrence of unusual fluxional behavior involving the [Pt(II) ] and [Au(I) ] metal fragments.

Preparation of Pt-Tl clusters showing new geometries. X-ray, NMR and luminescence studies.

Square planar complexes [Pt(CNC)L] (CNC = C,N,C-2,6-NC5H3(C6H4-2)2; L = tht (tetrahydrothiophene, SC4H8, 1), L = CN(t)Bu (2)) react with TlPF6 in different Pt/Tl molar ratios (3/1 in the case of 1 and 1/1 in the case of 2) yielding the complexes [{Pt(CNC)(tht)}3Tl](PF6) (3) and [Pt(CNC)(CN(t)Bu)Tl](PF6) (4), respectively. The structures of 3 and 4 (X-ray) show the presence of Pt→Tl dative bonds unsupported by any bridging ligands. In complex 3, the only Tl centre is simultaneously bonded to three Pt atoms forming a perfect equilateral triangle with Pt-Tl distances of 2.

Synthesis, characterization, and computational study of complexes containing Pt···H hydrogen bonding interactions.

Complexes [Pt(C6F5)(bzq)L] (bzq = 7,8-benzoquinolinate; L = 8-hydroxyquinoline, hqH (1); 2-methyl-8-hydroxyquinoline, hqH' (2)) have been prepared by replacing the labile acetone ligand in the starting material [Pt(C6F5)(bzq)(Me2CO)]. The (1)H NMR spectra of 1 and 2 show that the signals attributable to the hydroxyl proton of the hqH or hqH' ligands are displaced downfield 2.64 ppm for 1 and 2.

Synthesis and characterization of a "Pt3Tl" cluster containing an unprecedented trigonal environment for thallium(I).

The tetranuclear [{Pt(CNC)(tht)}3Tl](PF6) (tht = tetrahydrothiophene; SC4H8; CNC = C,N,C-2,6-NC5H3(C6H4-2)2; 2) cluster has been prepared by the reaction of [Pt(CNC)(tht)] (1) and TlPF6 (molar ratio 3:1) and structurally characterized. The Tl(I) atom is bonded to three Pt(II) centers bearing a perfect trigonal coordination. The Pt(II)-Tl(I) bonds are unsupported by any bridging ligand and are the shortest of this kind reported so far [2.