Publications by authors named "Ursa Bezan Petric"
Highly bioavailable inorganic phosphate (Pi) is present in large quantities in the typical Western diet and represents a large fraction of total phosphate intake. Dietary Pi excess induces exercise intolerance and skeletal muscle mitochondrial dysfunction in normal mice. However, the relevance of this to humans remains unknown.
View Article and Find Full Text PDFObjective: The aim of the present systematic review is to synthesize existing evidence (qualitative and quantitative) regarding age- and sex-specific differences with glenohumeral osteoarthritis.
Design: The electronic databases PubMed, MEDLINE, and Web of Science were searched up to March 15, 2023. Articles reporting on the association of risk factors (age and sex) with glenohumeral osteoarthritis were considered.
Background: SGLT2i (sodium-glucose cotransporter 2 inhibitor), a class of anti-diabetic medications, is shown to reduce blood pressure (BP) in hypertensive patients with type 2 diabetes. Mechanisms underlying this action are unknown but SGLT2i-induced sympathoinhibition is thought to play a role. Whether SGLT2i reduces BP and sympathetic nerve activity (SNA) in a nondiabetic prehypertension model is unknown.
View Article and Find Full Text PDFArticle Synopsis
- The neonatal mammalian heart can regenerate shortly after birth, but this ability diminishes within the first week as the heart shifts from using anaerobic glycolysis to fatty-acid metabolism for energy.
- High rates of reactive oxygen species generated during fatty-acid oxidation may cause DNA damage and prevent heart cell (cardiomyocyte) division.
- Research involving fat-deficient diets and specific genetic modifications in mice demonstrated that inhibiting fatty-acid use enhances cardiomyocyte proliferation and improves heart recovery after damage, suggesting new potential strategies for cardiac regeneration therapy.