Renal AAV2-Mediated Overexpression of Long Non-Coding RNA Attenuates Ischemic Acute Kidney Injury Through Sponging of microRNA-30a-5p.

Background: Renal ischemia-reperfusion (I/R) injury is a major cause of AKI. Noncoding RNAs are intricately involved in the pathophysiology of this form of AKI. Transcription of hypoxia-induced, long noncoding RNA , which shows high embryonic expression and is silenced in adults, is upregulated in renal I/R injury.