Both electrical and metabolic coupling shape the collective multimodal activity and functional connectivity patterns in beta cell collectives: A computational model perspective.

Pancreatic beta cells are coupled excitable oscillators that synchronize their activity via different communication pathways. Their oscillatory activity manifests itself on multiple timescales and consists of bursting electrical activity, subsequent oscillations in the intracellular Ca^{2+}, as well as oscillations in metabolism and exocytosis. The coordination of the intricate activity on the multicellular level plays a key role in the regulation of physiological pulsatile insulin secretion and is incompletely understood.

Determinants of collective failure in excitable networks.

We study collective failures in biologically realistic networks that consist of coupled excitable units. The networks have broad-scale degree distribution, high modularity, and small-world properties, while the excitable dynamics is determined by the paradigmatic FitzHugh-Nagumo model. We consider different coupling strengths, bifurcation distances, and various aging scenarios as potential culprits of collective failure.