Publications by authors named "Urmas Savolainen"
Article Synopsis
- Spinal fusion surgery results in severe pain, and while strong opioids like oxycodone are commonly used, they can have side effects; this study explored the use of S-ketamine as an adjunct to help reduce opioid consumption.
- In a randomized, double-blind trial with 107 patients, different doses of S-ketamine were compared to placebo in conjunction with oxycodone patient-controlled analgesia (PCA) following major lumbar spinal fusion surgery.
- Results showed that the highest dose of 0.75 mg/ml S-ketamine led to a 25% reduction in cumulative oxycodone use and improved pain intensity at rest without increasing adverse effects compared to lower doses or oxycodone alone.
