ω Meson from Lattice QCD.

Many excited states in the hadron spectrum have large branching ratios to three-hadron final states. Understanding such particles from first principles QCD requires input from lattice QCD with one-, two-, and three-meson interpolators as well as a reliable three-body formalism relating finite-volume spectra at unphysical pion mass values to the scattering amplitudes at the physical point. In this work, we provide the first-ever calculation of the resonance parameters of the ω meson from lattice QCD, including an update of the formalism through matching to effective field theories.

Inclusive Hadronic Decay Rate of the τ Lepton from Lattice QCD: The u[over ¯]s Flavor Channel and the Cabibbo Angle.

We present a lattice determination of the inclusive decay rate of the process τ↦X_{us}ν_{τ} in which the τ lepton decays into a generic hadronic state X_{us} with u[over ¯]s flavor quantum numbers. Our results have been obtained in n_{f}=2+1+1 isosymmetric QCD with full nonperturbative accuracy, without any operator product expansion approximation and, except for the presently missing long-distance isospin-breaking corrections, include a solid estimate of all sources of theoretical uncertainties. This has been possible by using the Hansen-Lupo-Tantalo method [M.

Probing the Energy-Smeared R Ratio Using Lattice QCD.

We present a first-principles lattice QCD investigation of the R ratio between the e^{+}e^{-} cross section into hadrons and into muons. By using the method of Ref. [1], that allows one to extract smeared spectral densities from Euclidean correlators, we compute the R ratio convoluted with Gaussian smearing kernels of widths of about 600 MeV and central energies from 220 MeV up to 2.

Exploiting protease activation for therapy.

Proteases have crucial roles in homeostasis and disease; and protease inhibitors and recombinant proteases in enzyme replacement therapy have become key therapeutic applications of protease biology across several indications. This review briefly summarises therapeutic approaches based on protease activation and focuses on how recent insights into the spatial and temporal control of the proteolytic activation of growth factors and interleukins are leading to unique strategies for the discovery of new medicines. In particular, two emerging areas are covered: the first is based on antibody therapies that target the process of proteolytic activation of the pro-form of proteins rather than their mature form; the second covers a potentially new class of biopharmaceuticals using engineered, proteolytically activable and initially inactive pro-forms of antibodies or effector proteins to increase specificity and improve the therapeutic window.

Erratum to: Topical issue on Lattice Field Theory during the Covid-19 pandemic.

[This corrects the article DOI: 10.1140/epja/s10050-021-00614-5.].

Quark and Gluon Momentum Fractions in the Pion from N_{f}=2+1+1 Lattice QCD.

We perform the first full decomposition of the pion momentum into its gluon and quark contributions. We employ an ensemble generated by the Extended Twisted Mass Collaboration with N_{f}=2+1+1 Wilson twisted mass clover fermions at maximal twist tuned to reproduce the physical pion mass. We present our results in the MS[over ¯] scheme at 2 GeV.

Ruling Out the Massless Up-Quark Solution to the Strong CP Problem by Computing the Topological Mass Contribution with Lattice QCD.

The infamous strong CP problem in particle physics can in principle be solved by a massless up quark. In particular, it was hypothesized that topological effects could substantially contribute to the observed nonzero up-quark mass without reintroducing CP violation. Alternatively to previous work using fits to chiral perturbation theory, in this Letter, we bound the strength of the topological mass contribution with direct lattice QCD simulations, by computing the dependence of the pion mass on the dynamical strange-quark mass.

Dynamical Generation of Elementary Fermion Mass: First Lattice Evidence.

Using lattice simulations we demonstrate from first principles the existence of a nonperturbative mechanism for elementary particle mass generation in models with gauge fields, fermions, and scalars, if an exact invariance forbids power divergent fermion masses and fermionic chiral symmetries broken at UV scale are maximally restored. We show that in the Nambu-Goldstone phase a fermion mass term, unrelated to the Yukawa operator, is dynamically generated. In models with electroweak interactions weak boson masses are also generated, opening new scenarios for beyond the standard model physics.

Combining rheology and MRI: Imaging healthy and tumorous brains based on mechanical properties.

Purpose: It is well known that pathological changes in tissue alter its mechanical properties. This holds also true for brain tissue. In case of the brain, however, obtaining information about these properties is hard due to the surrounding cranial bone.

Combinatorial Screening Identifies Novel Promiscuous Matrix Metalloproteinase Activities that Lead to Inhibition of the Therapeutic Target IL-13.

The practical realization of disease modulation by catalytic degradation of a therapeutic target protein suffers from the difficulty to identify candidate proteases, or to engineer their specificity. We identified 23 measurable, specific, and new protease activities using combinatorial screening of 27 human proteases against 24 therapeutic protein targets. We investigate the cleavage of monocyte chemoattractant protein 1, interleukin-6 (IL-6), and IL-13 by matrix metalloproteinases (MMPs) and serine proteases, and demonstrate that cleavage of IL-13 leads to potent inhibition of its biological activity in vitro.

Pseudarthrosis after lumbar spinal fusion: the role of ¹⁸F-fluoride PET/CT.

Purpose: Painful pseudarthrosis is one of the most important indications for (revision) surgery after spinal fusion procedures. If pseudarthrosis is the source of recurrent pain it may require revision surgery. It is therefore of great clinical importance to ascertain if it is the source of such pain.

CGTase-catalysed cis-glucosylation of L-rhamnosides for the preparation of Shigella flexneri 2a and 3a haptens.

We report the enzymatic synthesis of α-D-glucopyranosyl-(1→4)-α-L-rhamnopyranoside and α-D-glucopyranosyl-(1→3)-α-L-rhamnopyranoside by using a wild-type transglucosidase in combination with glucoamylase and glucose oxidase. It was shown that Bacillus circulans 251 cyclodextrin glucanotransferase (CGTase, EC 2.1.

η and η' mixing from lattice QCD.

We present a lattice QCD computation of η and η' masses and mixing angles, for the first time controlling continuum and quark mass extrapolations. The results for M(η) = 551(8)(stat) (6)(yst) MeV and M(η') = 1006(54)(stat)(38)(syst)(+61)(ex) MeV are in excellent agreement with experiment. Our data show that the mixing in the quark flavor basis can be described by a single mixing angle of Ø = 46(1)(stat)(3)(syst)° indicating that the η' is mainly a flavor singlet state.

Hard beta and gamma emissions of 124I. Impact on occupational dose in PET/CT.

Aim: The hard beta and gamma radiation of 124I can cause high doses to PET/CT workers. In this study we tried to quantify this occupational exposure and to optimize radioprotection.

Methods: Thin MCP-Ns thermoluminescent dosimeters suitable for measuring beta and gamma radiation were used for extremity dosimetry, active personal dosimeters for whole-body dosimetry.

Structure of PBP-A from Thermosynechococcus elongatus, a penicillin-binding protein closely related to class A beta-lactamases.

Molecular evolution has always been a subject of discussions, and researchers are interested in understanding how proteins with similar scaffolds can catalyze different reactions. In the superfamily of serine penicillin-recognizing enzymes, D-alanyl-D-alanine peptidases and beta-lactamases are phylogenetically linked but feature large differences of reactivity towards their respective substrates. In particular, while beta-lactamases hydrolyze penicillins very fast, leading to their inactivation, these molecules inhibit d-alanyl-d-alanine peptidases by forming stable covalent penicilloyl enzymes.

A new family of cyanobacterial penicillin-binding proteins. A missing link in the evolution of class A beta-lactamases.

It is largely accepted that serine beta-lactamases evolved from some ancestral DD-peptidases involved in the biosynthesis and maintenance of the bacterial peptidoglycan. DD-peptidases are also called penicillin-binding proteins (PBPs), since they form stable acyl-enzymes with beta-lactam antibiotics, such as penicillins. On the other hand, beta-lactamases react similarly with these antibiotics, but the acyl-enzymes are unstable and rapidly hydrolyzed.