Publications by authors named "Upul Priyadharshana"
Effectiveness of selective antibiotics use in ESBL-related UTIs.
Aththanayaka Mudiyanselage Waththe Gedara Kasun Prabuddha Aththanayaka Gangulwitiya Gamage Yasodha Hansani Weerasinghe Nimsha Sevwandika Weerakkody Samarasinghe Herathge Gayani Geethika Samarasinghe Upul Priyadharshana
BMC Microbiol
September 2024
Article Synopsis
- Urinary tract infections (UTIs) affect millions globally, with a rising concern over Enterobacteriaceae species that produce extended-spectrum β-lactamases (ESBLs), making treatment more challenging.
- A study at a district hospital in Polonnaruwa analyzed 4386 urine specimens, revealing 200 cases with ESBL isolates, primarily E. coli, especially among patients aged 55-74 and predominantly from the In-Patient Department.
- The research highlighted Mecillinam and Nitrofurantoin as the most effective oral antibiotics against E. coli and other species, with Nitrofurantoin showing notable effectiveness against Klebsiella spp. and other Enterobacteriaceae.
Introduction: Community acquired urinary tract infections (CA-UTI) are commonly caused by Escherichia coli and Klebsiella spp which are known extended spectrum beta lactamase (ESBL) producers.
Objectives: To determine, the prevalence and characteristics of ESBL producing of E. coli and Klebsiella spp in the community, and the association of risk factors with ESBL CA-UTI.