Malignant transformation of oral leukoplakia: a follow-up study.

Objective: The main objective of the study was to identify the determinants that contribute to the malignant transformation of oral leukoplakia in a group of patients managed in secondary care. A secondary objective was to compare two dysplasia grading systems to determine their utility in assessing the prognosis.

Material And Methods: The cohort consisted of 93 patients diagnosed during the period 2009-2013.

Morphological changes in oral mucosae and their connective tissue cores regarding oral submucous fibrosis.

Oral submucous fibrosis (OSF) is a chronic disease of the oral cavity characterized by an inflammatory reaction followed by severe fibro-elastic changes. The aim of the present study was to investigate the three-dimensional morphological changes in the connective tissue cores (CTCs) of the oral mucosa in OSF. The sample consisted of buccal mucosal biopsies from ten human subjects ranging in age from 40-45 years; five of them were clinically diagnosed as having moderate to severe OSF, and the remaining five served as unaffected controls.