Publications by Upneet Sandhu

Publications by authors named "Upneet Sandhu"

Curr Opin Biotechnol

October 2007

Recombinase-based techniques for integrating transgenes into specific locations in mammalian cells are becoming more popular due to their precision and predictability.
This review examines different targeting strategies using site-specific recombinases like Cre, Flp, and PhiC31 for transgene integration.
It also discusses applications in areas such as protein expression, virus production, the creation of transgenic animals, and chromosome engineering.

Upneet Sandhu's recent research primarily focuses on recombinase-based targeting technologies for genome engineering, emphasizing their potential for precise transgene integration.
The article discusses the advantages of site-specific recombinases, such as Cre, Flp, and PhiC31, in achieving predictable transgene expression in mammalian cells.
Sandhu's work contributes to the understanding of recombinase-mediated cassette exchange (RMCE) as a promising strategy for genetic manipulation in biotechnology applications.