Publications by authors named "Upasana Pudupakkam"
J Lipid Res
February 2024
Article Synopsis
- ANGPTL3 is a liver protein that plays a role in managing lipid levels in the blood, specifically triglycerides and LDL cholesterol, but its exact functions in lipid assembly and secretion are unclear.
- Using CRISPR/Cas9 to alter ANGPTL3 in liver cells resulted in reduced secretion of a key component (ApoB100) necessary for lipoprotein production, more degradation of this component, and changes in lipid metabolism, such as enhanced fatty acid oxidation.
- The study also revealed that when ANGPTL3 is deficient but LDL receptors are present, it leads to fewer lipoprotein particles due to early assembly issues; however, if LDL receptors are deleted, the role of ANGPTL3 shifts to regulating degradation without
Article Synopsis
- SVEP1 is a protein linked to vascular disease and platelet activity in humans, with significant implications for cardiovascular health.
- Research identifies a strong interaction between SVEP1 and the receptor PEAR1, which leads to increased platelet activation and disease-related signaling pathways.
- Targeting the SVEP1-PEAR1 interaction could offer a promising new approach for treating or preventing cardiovascular and thrombotic diseases.
