Ribosome-associated quality control mediates degradation of the premature translation termination product Orf1p of ODC antizyme mRNA.

Decoding of OAZ1 (Ornithine decarboxylase AntiZyme 1) mRNA, which harbours two open reading frames (ORF1 and ORF2) interrupted by a naturally occurring Premature Termination Codon (PTC), produces an 8 kDa truncated polypeptide termed Orf1p, unless the PTC is bypassed by +1 ribosomal frameshifting. In this study, we identified Orf1p as an endogenous ubiquitin-dependent substrate of the 26S proteasome both in yeast and mammalian cells. Surprisingly, we found that the ribosome-associated quality control factor Rqc1 and the ubiquitin ligase Ltn1 are critical for Orf1p degradation.

Synthesis, characterization & evaluation of potential of silver nanoparticles mediated Linn bark extract.

Objective: The potential of silver nanoparticle(AgNP-AS) mediated bark extract of R.Br was investigated in the study.

Methods & Materials: AgNP-AS was synthesized with respect to optimal temperature, pH of extract.

Incidence and treatment of snakebites in West Bengal, India.

Objective: Snake envenomation is a major cause of death and disability in the developing countries. In India and neighboring countries, the four venomous snakes of concern include - Indian cobra(, Common Krait (); Russell's Viper (); Saw Scaled Viper (). We describe the management protocol for snakebite treatment in a tertiary care hospital of district, West Bengal based on case reports of subjects admitted and treated in Ghatal Subdivisional Hospital(GSH) during 2013-2016.