Publications by authors named "Upare Abhay Atmaram"
Article Synopsis
- - The review focuses on 5-membered heterocycles, specifically 1,2,4-oxadiazole and 1,3,4-thiadiazole, highlighting their importance in various drugs and natural products aimed at treating conditions like cancer and tuberculosis.
- - These compounds are noted for their chemical and heat resistance, making them effective bio-isosteric replacements in drug design, which is particularly relevant for their pharmacological properties.
- - The article emphasizes recent advancements in the synthesis and biological activities of these isomers over the past 5 years, providing a solid foundation for future research in drug development.
A convenient one step synthesis of chlorotrifluoroalkyl olefins starting from aldehydes was developed. The stable reagent 2-((1-chloro-2,2,2-trifluoroethyl)sulfonyl)benzothiazole was prepared from readily available benzothiazole-2-thiol and halothane. This method comprises using stable 2-((1-chloro-2,2,2-trifluoroethyl)sulfonyl)benzothiazole according to the Julia procedure and presents new opportunities for the synthesis of trifluoroalkylidene derivatives.
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