BMI, waist to height ratio and waist circumference as a screening tool for hypertension in hospital outpatients: a cross-sectional, non-inferiority study.

Objective: This non-inferiority study aimed to determine the burden of obesity in a hospital outpatient setting of a developing country, using three commonly employed metrics as predictors of hypertension (HTN).

Design: A cross-sectional study design was adopted.

Setting: This study was conducted in Health Promotion and Risk Factor Screening Services of a tertiary hospital for eye and ear, nose, throat in a semiurban area of Nepal.

Translation and Validation of Oral Health-Related Early Childhood Quality of Life Tool for Nepalese Preschool Children.

Background Early childhood caries (ECC) in preschool children debilitate their quality of life affecting oral function, appearance and social well-being. A tool for measuring oral health-related quality of life for preschoolers may help in making clinical decisions and assist policy makers in planning and management of health programs in the country. Objective To translate oral health-related early childhood quality of life (OH-ECQoL) tool into Nepali language and test its validity and reliability.

A proportional appraisal of smile perception by laypersons, dental professionals, and a smile designing software: An study.

Aim: To equivalence the perception of smile among laypersons, dental professionals and a commercially available popular smile designing software.

Settings And Design: In vivo - comparative study.

Materials And Methods: A total of 72 participants within age range of 18-30 years were randomly selected with a natural permanent dentition.

Influence of ligand geometry on cholinesterase enzyme - A comparison of 1-isoindolinone based structural analog with Donepezil.

Donepezil (DNPZ) is one of the few FDA-approved widely used medication in the clinical care of Alzheimer's disease (AD) patients. To investigate the effect of geometry and to find the significance of an enol form if any in DNPZ on acetylcholinesterase (AChE) inhibition, we changed the tetrahedral geometry of DNPZ to planar trigonal pyramidal geometry by replacing the α-carbon atom next to ketone functionality with a nitrogen atom. To mimic 1-indanone in DNPZ, we selected 1-isoindolinone framework to synthesize 25 new DNPZ derivatives and characterized using H NMR, C NMR and ESI-MS spectroscopy methods.

Millets Can Have a Major Impact on Improving Iron Status, Hemoglobin Level, and in Reducing Iron Deficiency Anemia-A Systematic Review and Meta-Analysis.

The prevalence of iron deficiency anemia is highest among low and middle-income countries. Millets, including sorghum, are a traditional staple in many of these countries and are known to be rich in iron. However, a wide variation in the iron composition of millets has been reported, which needs to be understood in consonance with its bioavailability and roles in reducing anemia.

Quality of condition suggestions and urgency advice provided by the Ada symptom assessment app evaluated with vignettes optimised for Australia.

When people face a health problem, they often first ask, 'Is there an app for that?'. We investigated the quality of advice provided by the Ada symptom assessment application to address the question, 'How do I know the app on my phone is safe and provides good advice?'. The app was tested with 48 independently created vignettes developed for a previous study, including 18 specifically developed for the Australian setting, using an independently developed methodology to evaluate the accuracy of condition suggestions and urgency advice.

Differential expression of circulating microRNAs in serum: Potential biomarkers to track Japanese encephalitis virus infection.

Japanese encephalitis is one of the serious vector-borne viral encephalitis diseases found worldwide and poses a major threat to public health. Most Japanese encephalitis virus (JEV) infections are subclinical; only 1: 250 to 1:1000 infected persons develop clinical presentations. Delay in proper diagnosis of JE affects the timeliness of treatment initiation and increases the mortality rate in patients.

Algorithm Change Protocols in the Regulation of Adaptive Machine Learning-Based Medical Devices.

One of the greatest strengths of artificial intelligence (AI) and machine learning (ML) approaches in health care is that their performance can be continually improved based on updates from automated learning from data. However, health care ML models are currently essentially regulated under provisions that were developed for an earlier age of slowly updated medical devices-requiring major documentation reshape and revalidation with every major update of the model generated by the ML algorithm. This creates minor problems for models that will be retrained and updated only occasionally, but major problems for models that will learn from data in real time or near real time.

Unlocking SGK1 inhibitor potential of bis-[1-N,7-N, pyrazolo tetraethoxyphthalimido{-4-(3,5-Dimethyl-4-(spiro-3-methylpyazolo)-1,7-dihydro-1H-dipyrazolo[3,4-b;4',3'-e]pyridin-8-yl)}]p-disubstituted phenyl compounds: a computational study.

SGK1 (Serum and Glucocorticoid Regulated Kinase 1), a serine/threonine kinase that is activated by various stimuli, including serum and glucocorticoids. It controls inflammation, apoptosis, hormone release, neuro-excitability and cell proliferation, all of which play an important role in cancer progression and metastasis. SGK1 was recently proposed as a potential drug target for cancer, diabetes, and neurodegenerative diseases.

Nurturing Beyond the Womb - Early Intervention Practices in Newborn Care Unit.

The survival of small and sick babies has increased over the last two decades, though at the cost of increasing the burden of neuro-morbidities. Early intervention (EI) capitalises on the unique characteristic of neuroplasticity that ameliorates the effect of insult to the developing brain during fetal and early infancy period. EI provides positive sensorimotor experiences and promotes neuro-behavioural maturation which can greatly mitigate adverse outcomes for these at-risk babies.

Compendium of Plant-Specific CRISPR Vectors and Their Technical Advantages.

CRISPR/Cas mediated genome editing is a revolutionary approach for manipulating the plant genome. However, the success of this technology is highly dependent on selection of a specific vector and the other components. A plant-specific CRISPR/Cas vector usually consists of a gene, target-specific gRNA, leader sequence, selectable marker gene, precise promoters, and other accessories.

Species richness and β-diversity patterns of macrolichens along elevation gradients across the Himalayan Arc.

Understanding the species richness and β-diversity patterns along elevation gradients can aid in formulating effective conservation strategies particularly in areas where local anthropogenic stresses and climate change are quite significant as in the Himalaya. Thus, we studied macrolichen richness and β-diversity along elevational gradients at three sites, namely Kashmir (2200 to 3800 m a.m.

Pro-inflammatory and anti-inflamatory cytokine genes polymorphisms and susceptibility to Japanese encephalitis disease in the North Indian population.

Background: Japanese encephalitis virus (JEV) is the major cause of viral encephalitis in many regions of Asia. Cytokines, including pro-inflammatory and anti-inflammatory are key regulators playing a detrimental role in the host response to JE infection, pathogenesis and disease outcome. Evidently, the host's cytokine response is genetically determined, representing the complexity of interindividual differences regarding immune response to viral infection.

Persistence of behavioral abnormalities following corticosteroid therapy in children with initial episode of idiopathic nephrotic syndrome: a prospective longitudinal observation.

Introduction: Treatment of nephrotic syndrome with corticosteroid can cause several side- effects including behavioral abnormalities. The objectives of the study were to observe the proportion of non-relapsers having persistence of behavioral abnormalities after completion of treatment of initial episode and compare the abnormalities with relapsers, and to determine risk factors for persistence.

Methods: Seventy-five children with a first episode of idiopathic nephrotic syndrome and 60 normal children were rated by parents for behavioral problems using the Child Behavior Checklist.

Hospital Cultural Competency and Attributes of Patient Safety Culture: A Study of U.S. Hospitals.

Objective: Given the increasing racial and ethnic diversity in the United States, hospitals face challenges in providing safe and high-quality care to minority patients. Cultural competency fostered through engagement in diversity programs can be used as a resourceful strategy to provide safe care and improve the patient safety culture. This article examined the association of cultural competency and employee's perceived attributes of safety culture.

Circulating Secretoglobin Family 1A Member 1 (SCGB1A1) Levels as a Marker of Biomass Smoke Induced Chronic Obstructive Pulmonary Disease.

Secretoglobin family 1A member 1 (SCGB1A1) alternatively known as club cell protein 16 is a protective pneumo-protein. Decreased serum levels of SCGB1A1 have been associated with tobacco smoke induced chronic obstructive pulmonary disease (TS-COPD). Exposure to biomass smoke (BMS) is an important COPD risk factor among women in low and lower-middle income countries.

Predicting personalised optimal arc parameter using knowledge-based planning model for inoperable locally advanced lung cancer patients to reduce organ at risk doses.

. Volumetric modulated arc therapy (VMAT) allows for reduction of organs at risk (OAR) volumes receiving higher doses, but increases OAR volumes receiving lower radiation doses and can subsequently increasing associated toxicity. Therefore, reduction of this low-dose-bath is crucial.

Role of 14-3-3β protein on ovarian folliculogenesis, steroidogenesis and its correlation in the pathogenesis of PCOS in mice.

This study was designed to assess for the first time the circulating and ovarian level of 14-3-3β protein in the PCOS mice and the possible correlation between 14-3-3β protein with PCOS related increase in testosterone (HA), insulin levels (HI) and reduced insulin sensitivity in the ovary. PCOS was induced in mice using treatment of letrozole (by oral gavage) for 21 days. Immunohistochemical study showed increased expression of 14-3-3β protein in PCOS ovary compared to the control ovary.

Mainstreaming Local Food Species for Nutritional and Livelihood Security: Insights From Traditional Food Systems of Community of Arunachal Pradesh, India.

This study brings out the critical role of lesser-known local plant species in the food, nutrition and livelihood security of community in Arunachal Pradesh, India. Considering women as a major custodian in knowledge and practices on foods, a total of 90 women and 60 key knowledgeable community members (thus a total of 150 participants) were selected from East Siang and Upper Siang districts of Arunachal Pradesh. Data were collected using combination of methods including recipe contest, focus group discussion, personal interviews and laboratory analyses.

Preceding child survival status and its effect on infant and child mortality in India: An evidence from National Family Health Survey 2015-16.

Background: India has achieved impressive gains in child survival over the last two decades; however, it was not successful in attaining MDG 2015 goals. The study's objective is to inquire how the survival status of the preceding child affects the survival of the next born child.

Methods: This is a retrospective analysis of data from the National Family Health Survey, 2015-16.

Validation of in-house knowledge-based planning model for predicting change in target coverage during VMAT radiotherapy to in-operable advanced-stage NSCLC patients.

. anatomical changes are inevitable during the course of radiotherapy treatments and, if significant, can severely alter expected dose distributions and affect treatment outcome. Adaptive radiotherapy (ART) is employed to maintain the planned distribution and minimise detriment to predicted treatment outcome.

The association of ABO blood group with the asymptomatic COVID-19 cases in India.

The COVID-19 pandemic resulted in multiple waves of infection worldwide. The large variations in case fatality rate among different geographical regions suggest that the human susceptibility against this virus varies substantially. Several studies from different parts of the world showed a significant association of ABO blood group and COVID-19 susceptibility.

Measuring the unseen: mobilizing citizen scientists to monitor groundwater in Nepal.

Groundwater-level monitoring provides crucial information on the nature and status of aquifers and their response to stressors like climate change, groundwater extraction, and land use changes. Therefore, the development of a spatially distributed long-term monitoring network is indispensable for sustainable groundwater resource management. Despite being one of our greatest unseen resources, groundwater systems are too often poorly understood, ineffectively managed, and unsustainably used.

Acute Pancreatitis in the Transgender Population.

Hypertriglyceridemia (HTG) is an uncommon but well-established etiology of acute pancreatitis (AP) leading to significant morbidity and mortality. Hormone replacement therapy in the transgender population is an underrecognized cause of elevated triglyceride (TG) levels and may put this group at a higher risk for severe pancreatitis. We present a case of AP in a genetically male patient receiving hormone therapy for female gender transformation.

Molecular docking and simulation studies of flavonoid compounds against PBP-2a of methicillin-resistant .

Methicillin-Resistant (MRSA), a pathogenic bacterium that causes life-threatening outbreaks such as community-onset and nosocomial infections as emerging 'superbug'. Time and motion study of its virulent property developed resistance against most of the antibiotics such as Vancomycin. Thereby, to curb this problem entails the development of new therapeutic agents.