Hospitalization Events Among Adolescents and Adults With Sickle Cell Disease in a Tertiary Care Center in Central India.

Background: Sickle cell disease (SCD) is an inherited red blood cell disorder, wherein mutation causes the substitution of glutamic acid to valine at the sixth position of the β-globin chain. These include sickle cell anemia (homozygous sickle mutation), sickle-beta thalassemia, and hemoglobin SCD. The clinical manifestations of SCD are protean.

An Incidental Finding of Low-Grade Appendiceal Mucinous Neoplasm in a Case of Borderline Brenner Tumor of the Ovary.

The concurrent presentation of a low-grade appendiceal mucinous neoplasm (LAMN) and a borderline Brenner tumor (BT) of the ovary are exceedingly rare. Brenner tumors stand out as a particularly uncommon form, making up only around 5% of all benign epithelial tumors of the ovary. Among the ovarian Brenner, the borderline subtype is even rarer.

Hydrogeochemical signatures of spring water in geologically diverse terrains: a case study of Southern Western Ghats, India.

Out of 5 million Indian spring water systems, a few were characterised for hydrochemistry and freshwater potential. The present study focuses on analysing the hydrochemistry, discharge, and drinking/irrigation water quality of both cold and thermal spring clusters namely Southern Kerala Springs (SKS) and Dakshina Kannada Springs (DKS) of Southern Western Ghats, India. Currently, eleven springs from SKS and ten from DKS including one thermal spring (TS) with temperature ranges from 34 to 37 °C were considered.

Low-temperature Co-precipitation Synthesis of ZnAlO Nanophosphors Probing its Luminescent, Antibacterial and Anticancer Potentials.

Metal nanoparticles and their binary oxides are well-known for their interactions with biomolecules and their applications in the biomedical field. However, the potential of ternary oxide nanophosphors remains underexplored in these fields due to challenges associated with high-temperature synthesis procedures and the use of toxic chemicals. ZnAlO, a ternary oxide matrix, being recognized for its adjustable wide bandgap, impressive surface properties, mechanical strength, thermal stability, and high quantum yield, is chosen for the present work.

Antibiotic Susceptibility Profiling of Gram-Positive and Gram-Negative Bacterial Isolates in a Tertiary Care Hospital: Establishment of an Antibiogram.

Introduction Antimicrobial resistance poses a significant global healthcare challenge in the management of bacterial infections, which is frequently attributed to rapid bacterial adaptations. This study aims to develop an antibiogram for a tertiary care hospital, providing comprehensive antibiotic sensitivity profiles for Gram-positive and Gram-negative bacteria. It informs healthcare providers of antibiotic resistance trends, enabling informed treatment decisions and enhanced infection control measures.

Association of CYP27B1 gene polymorphisms with pulmonary tuberculosis and vitamin D levels.

Background And Objectives: Genetic factors are reported to be connected with tuberculosis (TB) infection. Studies have shown that genetic variations in genes involved in the vitamin D pathway influence the levels of vitamin D found in the bloodstream (serum). Cyp27b1 (1α-hydroxylase) is an enzyme that activates the synthesis of bioactive vitamin D by hydroxylation of 25(OH)DThe in vitro studies reported rare gene variants of Cyp27b1 such as rs118204011 and rs118204012, associated with loss of Cyp27b1 function and lower serum vitamin D levels.

Addressing the Global Threat of Multidrug-Resistant Infections: The Role of Ceftazidime-Avibactam Revisited.

Background and objective Bloodstream infections (BSIs) due to multidrug-resistant Gram-negative bacteria (MDR-GNB) pose a significant global health threat amid rising antimicrobial resistance (AMR). This study aimed to investigate the efficacy of ceftazidime-avibactam (CZA) as a therapeutic option for these infections, addressing the urgent need for novel treatments. Materials and methods This study was conducted over one year in the Department of Microbiology, JSS Medical College and Hospital, Mysuru, India, and employed a laboratory-based prospective design.

Evaluation of Cardiospermum halicacabum on Bone Morphogenetic Protein-2 (BMP2) mRNA Expression in Osteoblast Cells.

Introduction Maintaining bone health is crucial for overall well-being, with osteoblasts playing a vital role in bone formation. Bone morphogenetic protein-2 (BMP2) is a key regulator, stimulating bone matrix synthesis and osteoblast differentiation. Recognizing BMP2's significance, there's growing interest in natural compounds, such as .

Adams-Oliver syndrome associated with refractory glaucoma.

Adams-Oliver syndrome (AOS) is a rare inherited disorder characterized by aplasia cutis congenita, cutis marmorata telangiectatica congenita, and terminal limb defects. Ocular associations have been rarely reported. We report a 6-month-old boy with AOS associated with refractory glaucoma, megalocornea, and anterior polar cataract.

Application of an ensemble CatBoost model over complex dataset for vehicle classification.

The classification of vehicles presents notable challenges within the domain of image processing. Traditional models suffer from inefficiency, prolonged training times for datasets, intricate feature extraction, and variable assignment complexities for classification. Conventional methods applied to categorize vehicles from extensive datasets often lead to errors, misclassifications, and unproductive outcomes.

Optimizing Antibiotic Treatment for Diabetic Foot Infections: A Study From a Tertiary Public Healthcare Center in Puducherry, South India.

Background: Diabetic foot infections (DFIs) represent a significant complication of diabetes mellitus, contributing to increased morbidity and mortality. Understanding antibiotic prescribing patterns and microbial susceptibility is crucial for effective management.

Objective: This study aimed to assess antibiotic prescribing trends and microbial susceptibility patterns in DFIs in a tertiary care center in Puducherry.

Quality of life in postmenopausal women and its association with sarcopenia.

Objectives: With the menopausal transition, there is a decline in estrogen concentration with potential health consequences affecting the quality of life. The loss of muscle mass, strength, and function, known as sarcopenia is common in postmenopausal women. The primary objective of this study is to assess the quality of life in postmenopausal women and its association with sarcopenia.

Design and implementation of a high misalignment-tolerance wireless charger for an electric vehicle with control of the constant current/voltage charging.

Wireless charging of Electric Vehicles (EVs) has been extensively researched in the realm of electric cars, offering a convenient method. Nonetheless, there has been a scarcity of experiments conducted on low-power electric vehicles. To establish a wireless power transfer system for an electric vehicle, optimal power and transmission efficiency necessitate arranging the coils coaxially.

Verbal Abuse in Schools: Analyzing the Features of Teachers' Verbal Abuse From the Linguistic Perspective.

This study aims to investigate the forms of verbal abuse by teachers toward students during the teaching and learning process, the prototype of verbal abuse recognized by teachers, and the specific features of verbal abuse of students by teachers. This study used mixed methods that combine qualitative and quantitative methods. The quantitative method focused on investigating the frequency of verbal abuse by teachers using the Korean Verbal Abuse Questionnaire.

Fine-tuning digital FIR filters with gray wolf optimization for peak performance.

The design of optimum filters constitutes a fundamental aspect within the realm of signal processing applications. The process entails the calculation of ideal coefficients for a filter in order to get a passband with a flat response and an unlimited level of attenuation in the stopband. The objective of this work is to solve the FIR filter design problem and to compare the optimal solutions obtained from evolutionary algorithms.

Effects of seasons and successive upwelling phases on phytoplankton size classes in the Southeast Arabian Sea.

The responses of Phytoplankton Size Classes (PSCs) to seasons and the distinct phases of coastal upwelling in the northern Indian Ocean is an understudied aspect. This study introduces observations from a monthly time series conducted at three cross-shore transects in the south, central, and north regions between 6 and 13°N along the southwest coast of India in the Southeastern Arabian Sea (SEAS). The data represent pre-upwelling (late April to early May), early upwelling (early to mid-June), peak upwelling (early to mid-August), late upwelling (mid to late September), and post-upwelling (late October to early November) phases.

Inventory and management of E-waste: a case study of Kerala, India.

The recent surge in electronic device usage has led to a notable rise in electronic waste (E-waste) generation, presenting significant environmental challenges. This study aims to quantify Kerala's E-waste inventory and formulate a comprehensive management plan. Utilizing sales data from 2017 to 2020 and estimating E-waste generation based on "average" or "end-of-life" durations of electrical and electronic equipment (EEE) items, the analysis forecasts substantial E-waste quantities.

Case Report: Holistic dental care for a child with Hunter syndrome: Addressing dental ramifications, overcoming challenges, and enhancing quality of life.

Hunter syndrome (MPS II), an X-linked recessive lysosomal storage disorder, is a result of deficiency of the iduronate 2-sulfatase enzyme (IDS), leading to cognitive impairment, systemic organ involvement, and increased dental problems. This case report describes the management of a child with Hunter syndrome who was referred to the Department of Paediatric and Preventive Dentistry for pain in the upper front teeth. Intraoral examination revealed severe early childhood caries, prompting planning for full-mouth rehabilitation under general anaesthesia due to the child's uncooperative behaviour.

A Review of Connecting Bioinformatic Techniques to Rheumatoid Arthritis and its Associated Comorbidities.

Rheumatoid Arthritis (RA) is a progressive autoimmune condition inflicting serious threats to people's life and health by causing severe pain and joint destruction. It affects not only bones and joints but also causes comorbid conditions and shortens the lifetime. The interactions and synergistic effects of comorbid disease with RA are not yet well studied.

In Vitro Wound Healing and Anticancer Effects of Ixora coccinea in Malignant Melanoma Cell Lines.

Background is a medicinal plant with many active constituents that are responsible for wound healing and have anticancer properties. Herbal extracts increase the mechanisms related to wound healing, like blood clotting, fighting infection, and epithelialization. The effect responsible for this property may be the presence of phytoconstituents like flavonoids, polyphenols, and alkaloids.