Current Status and Future Directions in the Development of Digital Therapeutic Interventions for Neurodevelopmental Disorders.

Innovations in digital technologies have emerged digital therapeutics (DTx) as a novel therapeutic intervention. DTx hold potential as novel theragnostics for disorders with broad diagnostic spectra, including neurodevelopmental diseases (NDDs). In this review, we highlight challenging factors in the successful development and deployment of DTx for NDDs with respect to patients, medical professionals, and manufacturers.

Carbohydrate-based diet may increase the risk of cardiovascular disease: A pooled analysis of two prospective cohort studies.

Background & Aims: According to cumulative epidemiologic studies, balancing macronutrients for energy is important to prevent metabolic diseases; however, this has not been studied extensively in Asian populations whose carbohydrate intake levels are relatively high. Therefore, we aimed to investigate the longitudinal association between carbohydrate intake and cardiovascular disease (CVD) among Korean adults in two community-based cohort studies.

Methods: We included 9608 and 164,088 participants from the Korean Association Resource and Health Examinee studies, respectively, in the analysis.

Carbohydrate Intake and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis of Prospective Studies.

The purpose of this study is to understand the conflicting results from previous studies on the association between carbohydrate intake and cardiovascular disease (CVD) by conducting a systematic review and meta-analysis to summarize the most recent scientific evidence. A systematic review used three electronic databases to gather literature on the association between carbohydrate intake and CVD. Considering the discrepancies, either fixed or random effect models were chosen to determine the effect size, and sensitivity analysis results, as well as publication bias, were also presented.

Phytochemical index and hypertension in Korean adults using data from the Korea National Health and Nutrition Examination Survey in 2008-2019.

Background/objectives: Although previous in vivo and in vitro studies have reported the beneficial effects of phytochemical-rich food on cardiovascular health, limited information is available regarding its' health effect on the community-dwelling population. This is especially true in Korea. Here, we examined the cross-sectional association between phytochemical levels and hypertension in Korean adults.