Should I stay or should I go? The role of daily presenteeism as an adaptive response to perform at work despite somatic complaints for employee effectiveness.

Our study seeks to contribute to scholarly understanding of the antecedents and consequences of the crucial, but so far overlooked within-person daily fluctuations in presenteeism. Drawing on theoretical frameworks of presenteeism, which conceptualize presenteeism as an adaptive behavior to deliver work performance despite limitations due to ill-health, we develop a within-person model of daily presenteeism and examine somatic complaints and work-goal progress as crucial joint determinants of daily fluctuations in presenteeism. We further integrate the aforementioned theoretical frameworks with ego-depletion theory to argue that presenteeism requires self-regulation to suppress cognitions, emotions, and behavioral responses associated with ill-health and instead focus on completing one's work tasks.

Correlation of clinical sepsis definitions with microbiological characteristics in patients admitted through a sepsis alert system; a prospective cohort study.

Background: Sepsis was recently redefined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. With this redefinition (Sepsis-3), clinical and microbiological characteristics of patients with sepsis may differ from the patients fulfilling the previous definition (Sepsis-2).

Purpose: To describe differences in clinical and microbiological characteristics of sepsis episodes between Sepsis-3 and Sepsis-2.

Cutaneous tuberculosis: epidemiological, clinical, diagnostic and therapeutic update.

Tuberculosis is certainly one of the diseases considered to be ancient on planet Earth. The etiological agent of tuberculosis is Mycobacterium tuberculosis. This terrible bacterial infection still results in severe socioeconomic consequences to date, and its complete eradication represents a great challenge.

Neuronal current imaging: An experimental method to investigate electrical currents in dogs with idiopathic epilepsy.

Background: The diagnosis of idiopathic epilepsy (IE) in dogs is based on exclusion of other potential causes of seizures. Recently, a novel magnetic resonance imaging (MRI) sequence that utilizes a variant of the rotary saturation approach has been suggested to detect weak transient magnetic field oscillations generated by neuronal currents in humans with epilepsy.

Hypothesis/objectives: Effects on the magnetic field evoked by intrinsic epileptic activity can be detected by MRI in the canine brain.

Stop and go, where is my flow? How and when daily aversive morning commutes are negatively related to employees' motivational states and behavior at work.

Despite convincing evidence about the general negative consequences of commuting for individuals and societies, our understanding of how aversive commutes are linked to employees' effectiveness at work is limited. Drawing on theories of self-regulation and by extension a conservation of resources perspective, we develop a framework that explains how an aversive morning commute-a resource-depleting experience characterized by interruptions of automated travel behaviors-impairs employees' immersion in uninterrupted work (i.e.

Use of the brief Confusion Assessment Method in a veteran palliative care population: A pilot validation study.

Objective: Many patients with advanced serious illness or at the end of life experience delirium, a potentially reversible form of acute brain dysfunction, which may impair ability to participate in medical decision-making and to engage with their loved ones. Screening for delirium provides an opportunity to address modifiable causes. Unfortunately, delirium remains underrecognized.

E-cigarettes/electronic nicotine delivery systems: a word of caution on health and new product development.

This paper describes the introduction, development, and proliferation of new electronic nicotine delivery systems (ENDS). The use of non-combustible tobacco products is considered a means for improving public health and reducing the mortality attributed to cigarette smoking. The effects and use of ENDS are described, with studies to date indicating that, despite differences in toxicity, there is insufficient evidence that ENDS leads to smoking cessation.

Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis.

Loss-of-function mutations in progranulin, a lysosomal glycoprotein, cause neurodegenerative disease. Progranulin haploinsufficiency causes frontotemporal dementia (FTD) and complete progranulin deficiency causes neuronal ceroid lipofuscinosis (NCL). Progranulin replacement is a rational therapeutic strategy for these disorders, but there are critical unresolved mechanistic questions about a progranulin gene therapy approach, including its potential to reverse existing pathology.

Click yes to consent: Acceptability of incorporating informed consent into an internet-based testing program for sexually transmitted and blood-borne infections.

Background: Autonomous use of online health care services without interaction with a health care provider challenges existing models for achieving informed consent (IC); current examinations of this issue have focused on commercial direct-to-consumer genetic testing. As IC is integral to publicly funded clinical testing services, we incorporated pre-test concepts necessary for IC in GetCheckedOnline (GCO), British Columbia's online sexually transmitted and blood-borne infection (STBBI) testing service.

Objective: We assessed the acceptability of this IC step and its design options among potential users during usability testing of GCO.

Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia.

Loss-of-function mutations in progranulin (GRN), a secreted glycoprotein expressed by neurons and microglia, are a common autosomal dominant cause of frontotemporal dementia, a neurodegenerative disease commonly characterized by disrupted social and emotional behaviour. GRN mutations are thought to cause frontotemporal dementia through progranulin haploinsufficiency, therefore, boosting progranulin expression from the intact allele is a rational treatment strategy. However, this approach has not been tested in an animal model of frontotemporal dementia and it is unclear if boosting progranulin could correct pre-existing deficits.

Covert Administration of Medication to Persons with Dementia: Exploring Ethical Dimensions.

The literature, although sparse, reports that covert administration of all types of medications is prevalent in nursing homes. Whether it is ever ethically defensible, however, to administer medications covertly to persons with significant dementia is a complex and contentious question. Some scholars contend that deception is inherently wrong and is never acceptable, while others believe that deception is intrinsic to providing care to persons with dementia.

The cytotoxic T cells may contribute to the in situ immune response in Jorge Lobo's Disease human lesions.

Jorge Lobo's Disease (JLD) is a cutaneous chronic granulomatous disease caused by the pathogenic fungus Lacazia loboi. It is characterized by a granulomatous reaction with multinucleated giant cells and high number of fungal cells. In order to contribute to the comprehension of immune mechanisms in JLD human lesions, we studied the cytotoxic immune response, focusing on TCD8+ and NK cells, and granzyme B.

Predicting Air Traffic Controller Workload: Trajectory Uncertainty as the Moderator of the Indirect Effect of Traffic Density on Controller Workload Through Traffic Conflict.

Objective: Our study investigates whether trajectory uncertainty moderates the relationship between traffic conflict and workload. Furthermore, we examine if the indirect effect of traffic density on workload through traffic conflict is conditional on the presence of trajectory uncertainty.

Background: Although it is widely accepted that uncertainty related to the future trajectory of an aircraft impacts air traffic controller decision making, little is known about how the presence of trajectory uncertainty impacts controller workload.

Th17 and regulatory T cells contribute to the in situ immune response in skin lesions of Jorge Lobo's disease.

Jorge Lobo's disease (JLD) is a chronic granulomatous mycosis described in various Latin American countries. The main objective of the present study was to investigate the possible role of Th17 and Foxp3+ Treg cells in the pathogenesis of Jorge Lobo's disease. Human skin biopsies were submitted to an immunohistochemistry protocol to detect Foxp3, interleukin (IL)-1beta, CD25, IL-6, IL-17, and IL-23.

Preventive Ethics Through Expanding Education.

Healthcare institutions have been making increasing efforts to standardize consultation methodology and to accredit both bioethics training programs and the consultants accordingly. The focus has traditionally been on the ethics consultation as the relevant unit of ethics intervention. Outcome measures are studied in relation to consultations, and the hidden assumption is that consultations are the preferred or best way to address day-to-day ethical dilemmas.

Supplemental Cardioplegia Immediately before Graft Implantation may Improve Early Post-Transplantation Outcome.

Background: Preservation of cardiac grafts for transplantation is not standardized and most centers use a single administration of crystalloid solution at the time of harvesting. We investigated possible benefits of an additional dose of cardioplegia dispensed immediately before implantation.

Methods: Consecutive adult cardiac transplantations (2005-2012) were reviewed.

Jorge Lobo's disease: immunohistochemical characterization of dendritic cells in cutaneous lesions.

Background: Jorge Lobo's disease (JLD) is a cutaneous chronic mycosis caused by Lacazia loboi. We studied Factor XIIIa + dermal dendrocytes (FXIIIa + DD), Langerhans cells (LC) through the expression of langerin and the expression of S100 protein.

Methods: A total of 41 biopsies and 10 normal skins (control) were developed with a polymer-based immunohistochemical method.

Impact of pond aquaculture effluents on seagrass performance in NE Hainan, tropical China.

The impact of pond aquaculture effluents on the distribution and performance of seagrasses was examined in NE Hainan, tropical China. Samples were taken along transects in three back-reef areas with different extent of aquaculture production in their hinterland. High δ(15)N in seagrass leaves and epiphytes (6-9‰) similar to values in pond effluents documented aquaculture as dominant nitrogen source in the back-reefs with decreasing impact with distance from shore.

Plasmacytoid dendritic cells in cutaneous lesions of patients with chromoblastomycosis, lacaziosis, and paracoccidioidomycosis: a comparative analysis.

Plasmacytoid dendritic cells (pDCs) are characterized by expression of CD123 and BDCA-2 (Blood Dendritic Cell Antigen 2) (CD303) molecules, which are important in innate and adaptive immunity. Chromoblastomycosis (CBM), lacaziosis or Jorge Lobo's disease (JLD), and paracoccidioidomycosis (PCM), are noteworthy in Latin America due to the large number of reported cases. The severity of lesions is mainly determined by the host's immune status and in situ responses.

Natural and human influences on nutrient transport through a small subtropical Chinese estuary.

Global understanding of land-ocean nutrient fluxes increasingly recognizes the disproportionate importance of small rivers. We studied nutrient fluxes from a small catchment in fast developing southern China to uncover effects of land-use. Water was sampled in the macro-tidal estuary of Nanliu River and adjacent Lianzhou Bay in spring and summer of investigate spatial and temporal variations of dissolved nutrients.