Ossicular reconstruction for incus long-process defects: bone cement or partial ossicular replacement prosthesis.

Objective: The objective of this study was to compare hearing results in patients undergoing ossiculoplasty with bone cement (BC) vs partial ossicular replacement prosthesis (PORP) in cases of incudostapedial discontinuity during tympanoplasty surgeries.

Study Design: Case series with chart review.

Setting: Tertiary referral center.

Endoscopic endonasal management of cerebrospinal fluid rhinorrhea.

The authors review their 5 years' experience with endonasal endoscopic repair of the anterior skull base fistulas presenting with cerebrospinal fluid (CSF) rhinorrhea. A total of 12 patients were managed endoscopically between 2004 and 2008. Seven patients (58.

Protective role of resveratrol against cisplatin induced ototoxicity in guinea pigs.

Objective: The aim of this study was to evaluate the effectiveness of systemic administration of resveratrol against cisplatin-induced ototoxicity in guinea pigs.

Materials And Methods: Healthy guinea pigs (n=24) were randomly divided into four groups. Group 1 (n=6) received resveratrol+cisplatin, group 2 (n=6) received 4% ethanol+cisplatin, group 3 (n=6) received cisplatin, and group 4 (n=6) received saline.

Pleomorphic adenomas recurrences within the parapharyngeal space.

This study was undertaken to evaluate and concentrate on the recurrent pleomorphic adenomas (PAs) of the parapharyngeal space. The records of 9 patients treated for recurrent PAs occupying parapharyngeal space were retrospectively reviewed. The study population comprised 6 women and 3 men with a mean age of 51 (range, 35-79 years).

Chemiluminescence assay of reactive oxygen species in laryngeal cancer.

Objective: This study aimed to evaluate the presence of reactive oxygen species in laryngeal cancer tissue, using a luminol-amplified chemiluminescence method.

Materials And Methods: Fourteen patients with histopathologically diagnosed laryngeal squamous cell carcinoma were enrolled. Patients with recurrent tumours or a history of prior chemotherapy or radiotherapy were excluded.

Histologic changes in eustachian tube mucosa of rats after exposure to gastric reflux.

Objective: Reflux is thought to be a risk factor for middle ear disease, but the mechanism underlying this relationship is unclear. In this study, we evaluated the effects of reflux on the eustachian tube (ET) mucosa.

Materials And Methods: Twenty-two healthy 150 to 220 g Wistar rats with normal middle ears were used.

Primary malignant melanoma of the middle ear mucosa: a case report.

Primary involvement of the middle ear and mastoid mucosa by malignant melanoma (MM) has been rarely reported. We report an 81-year-old Caucasian woman presenting with otalgia, left-sided aural fullness, and hearing loss. Otoscopic examination revealed a purple-colored polyp that appeared to be vascular, occupy left external auditory canal (EAC).

Vitamin e-coated tympanostomy tube insertion decreases the quantity of free radicals in tympanic membrane.

Objective: Tympanosclerosis is a common sequela of ventilation tube treatment of otitis media with effusion causing hearing disability. It is associated with an increased production of free radicals (also known as reactive oxygen species) after myringotomy. Vitamin E is a scavenger of different free radicals by working as an antioxidant.

Effects of vitamin E on cigarette smoke induced oxidative damage in larynx and lung.

Objectives: Cigarette smoke (CS) contains a large variety of compounds, including many oxidants and free radicals (also known as reactive oxygen species), that are capable of initiating or promoting oxidative damage, which leads to various degenerative pulmonary and cardiovascular diseases as well as cancer. Recent studies have established a strong relationship between CS and development of reactive oxygen species (ROS). The aim of the present study was to detect ROS levels in laryngeal and lung tissues of rats by measuring luminol-amplified chemiluminescence and to determine the changes in ROS levels in lung and laryngeal tissues induced by exposure to CS, with and without concurrent treatment with vitamin E.

The effect of Vitamin E treatment on the development of myringosclerosis after ventilation tube insertion.

Objectives: Recent studies have established the relationship between the reactive oxygen species and myringosclerosis. Furthermore several antioxidants have been known to prevent myringosclerosis. All the previous studies supporting this hypothesis have been performed on animals.

Determination of reactive oxygen species in nasal polyps.

A strong relationship between tissue damage and reactive oxygen species (ROS) has been established by previous studies. The aim of the current study was to evaluate the presence of ROS in nasal polyps (NP) by measuring luminol and lucigenin amplified chemiluminescence (CL). Three groups of specimens were studied.

Dynamic contrast-enhanced MRI in the differentiation of posttreatment fibrosis from recurrent carcinoma of the head and neck.

Objective: The aim of this study was to investigate the value of dynamic contrast-enhanced magnetic resonance imaging (MRI) in the differentiation of posttreatment fibrosis from recurrent carcinoma, by comparing the dynamic contrast-enhancement characteristics of the lesions.

Materials And Methods: Twenty-six patients with previously treated carcinoma of the head and neck are studied by conventional and dynamic contrast-enhanced MRI at least 6 months after treatment by radiotherapy and/or surgery. Patients are divided into tumor-positive or -negative groups according to the radiological and clinical follow-up and biopsy.

Giant intracranial Rosai-Dorfman disease.

Rosai-Dorfman disease is a rare, non-neoplastic disease characterized by an unusual proliferation of histiocytic cells. It rarely manifests intracranially, and only 50 cases of intracranial lesions have been reported. We describe an unusual case of a huge, solid mass in the paranasal sinuses, orbits, cavernous sinuses, and suprasellar cisterns.

Determination of reactive oxygen species in myringotomized tympanic membranes: effect of vitamin e treatment.

Objectives/hypothesis: Recent studies have established a strong relationship between the development of myringosclerosis and reactive oxygen species (ROS). The aims of the present study were to directly detect ROS in the tympanic membrane and middle ear mucosa of rats by measuring luminol amplified chemiluminescence, to evaluate the changes in the levels of ROS after treatment with vitamin E, and to examine the possible changes in the tympanic membranes otomicroscopically and histologically.

Study Design: Prospective controlled animal study.

Reflux of nasopharyngeal content into middle ear through the eustachian tube.

Whether nasopharyngeal content passes into the middle ear in patients without any head and neck pathology during the recovery phase of anesthesia is shown with an objective and prospective method. Thirty-eight patients, 21 female and 17 male, aged between 17 and 76, were included in the study. During the recovery phase of general anesthesia, 10 ml of 5 mCi Tc-99m-MAA was administered intranasally to the patients with a 10-F catheter.

Genetic predisposition for tympanosclerotic degeneration.

Atherosclerosis and tympanosclerosis are disorders that affect different organs in the body. When tissue samples taken from atherosclerotic and tympanosclerotic lesions are compared under light and electron microscopes, common pathological characteristics become apparent in both tissues. These similarities indicate that genetic predisposition to atherosclerosis is also seen in the middle ear.

Clinical importance of supratubal recess in cholesteatoma surgery.

Objective: To determine the importance of supratubal recess in cholesteatoma surgery by presenting the clinical presentation, imaging findings, and surgical treatment methods of 66 patients with cholesteatoma. We propose that the management of supratubal recess allows the opportunity for total removal of the cholesteatoma with the prevention of recurrence.

Study Design: Retrospective review of surgical cases.

Sex distribution in children with tympanosclerosis after insertion of a tympanostomy tube.

Tympanostomy tube insertion is an accepted treatment for otitis media with effusion in children. Several clinical studies have shown that tube insertion may cause myringosclerosis. During the period 1988 to 1997 we treated 533 ears from 311 children who had otitis media with effusion by inserting tympanostomy tubes.

The effect of endoscopic sinus surgery on mucociliary activity and healing of maxillary sinus mucosa.

The aim of this study was to determine histologic findings in the maxilaarysinus mucosa by scanning electron microscopy (SEM) and transmission electron microscopy (TEM), and ciliary activity within the nasal cavity by measuring the speed of mucociliary transport and after endoscopic sinus surgery (ESS). Thirty patients were enrolled. Thirty-eight antral mucosae of 24 24 patients were investigated according to ultrastructural changes and 6 patients were accepted as controls.

Aspiration of nasal secretions into the lungs in patients with acute sinonasal infections.

Objectives: To compare the amounts of nasal secretions aspirated into the lower airway by patients with acute sinonasal infection with that aspirated by healthy adults during sleep.

Study Design: Sixteen patients who had received a diagnosis of acute sinonasal infections by accurate history, anterior rhinoscopic examination, and radiological assessment and 13 healthy volunteers, aged 14 to 45 years.

Methods: A 10-mCi dose of technetium 99m-labeled macroaggregated albumin (Tc-99m MAA) with a concentration of 1 mCi/mL was prepared at midnight, just before sleep.

Treatment of chronic ear disease. Topical ciprofloxacin vs topical gentamicin.

Objective: To determine and compare the therapeutic efficiency of ciprofloxacin hydrochloride and gentamicin sulfate in the treatment of chronic ear disease.

Design: Prospective randomized study.

Setting: Academic tertiary medical center.

A case of Merkel cell carcinoma with parotid lymph node metastasis.

We report a case of Merkel cell carcinoma with parotid lymph node metastasis. The pathology, clinical appearance and management of this rare tumor are discussed.

Squamous epithelium in the middle ear and sinus.

This study has been performed between December 1990-March 1991 in the Microsurgery laboratory of the Marmara University Hospital. Twelve healthy albino guinea pigs were used as a study group while the control group consists of three animals. The potentials for cholesteatoma formation of the squamous epithelium, namely the squamous epithelium of the posterior superior part of the external ear canal skin and normal skin, were investigated.