The effect of osteoporosis education on osteoporosis knowledge level and daily life in Parkinson's disease patients: A 12-week, randomized-controlled trial.

Objectives: This study aims to evaluate the effect of osteoporosis education on osteoporosis knowledge level (OKL) and behavioral changes in daily life in patients with Parkinson's disease (PD).

Patients And Methods: Between May 2019 and December 2019, a total of 54 patients (34 males, 20 females; median age: 68.5 years; range, 50 to 87 years) were included in the study.

Agreement Between Office-Based and Laboratory-Based Globorisk Models and their Prediction of Cardiovascular Diseases in Turkish Population: A Nationwide Cohort Study.

Globorisk is a country-specific risk prediction model that estimates 10-year cardiovascular disease (CVD) risk. This study aims to evaluate the agreement between different versions of Globorisk and their ability to predict CVD in a nationwide Turkish cohort. Baseline data from 5449 participants aged 40-74 were obtained from Türkiye Chronic Diseases and Risk Factors Survey 2011.

The Prognostic Significance of Tumor Budding and Tumor-Infiltrating Lymphocytes in Patients Diagnosed With Malignant Melanoma.

The tumor microenvironment plays a critical role in malignant melanoma, influencing progression and patient outcomes, particularly through tumor budding (TB) and tumor-infiltrating lymphocytes (TILs). Despite the importance of TB, its detailed impact still needs to be explored, especially its interaction with TILs. This study evaluates the prognostic significance of TB and TILs in malignant melanoma, assessing their potential as indicators for disease progression and survival.

Immunological facets of prostate cancer and the potential of immune checkpoint inhibition in disease management.

Prostate cancer (PCa) is the most common non-cutaneous cancer in men and a major cause of cancer-related deaths. Whereas localized PCa can be cured by surgery and radiotherapy, metastatic disease can be treated, but is not curable. Inhibition of androgen signaling remains the main therapeutic intervention for treatment of metastatic PCa, in addition to chemotherapy, radionuclide therapy and emerging targeted therapies.

Molecular and In Silico Analysis of the Gene in Individuals with High Risk of Cancer Predisposition from Türkiye.

() is a tumor suppressor gene involved in DNA repair and cell cycle regulation. Pathogenic or likely pathogenic (P/LP) variants in are associated with increased cancer risk. Conversely, recent large cohort studies have identified certain variants that, despite being classified as P/LP by in silico analysis, are considered low risk.

Novel Variant in Muscular Dystrophy: Identification by Whole Genome Sequencing and Quad Analysis.

Background: The phenotypic spectrum of muscle disease ranges widely from elevated creatine kinase (CK) levels in the serum of asymptomatic individuals to progressive muscular dystrophy. Due to overlapping clinical features among muscular dystrophies, the diagnosis of muscle disease is established by molecular genetic tests. Early diagnosis is crucial for the clinical management of symptoms and to mitigate cardiac and musculoskeletal complications.

Targeting IRE1α reprograms the tumor microenvironment and enhances anti-tumor immunity in prostate cancer.

Unfolded protein response (UPR) is a central stress response pathway that is hijacked by tumor cells for their survival. Here, we find that IRE1α signaling, one of the canonical UPR arms, is increased in prostate cancer (PCa) patient tumors. Genetic or small molecule inhibition of IRE1α in syngeneic mouse PCa models and an orthotopic model decreases tumor growth.

Investigations of motor performance with neuromodulation and exoskeleton using leader-follower modality: a tDCS study.

This study investigates how the combination of robot-mediated haptic interaction and cerebellar neuromodulation can improve task performance and promote motor skill development in healthy individuals using a robotic exoskeleton worn on the index finger. The authors propose a leader-follower type of mirror game where participants can follow a leader in a two-dimensional virtual reality environment while the exoskeleton tracks the index finger motion using an admittance filter. The game requires two primary learning phases: the initial phase focuses on mastering the pinching interface, while the second phase centers on predicting the leader's movements.

Novel :c.2736delC Variant in Smith-Magenis Syndrome: Identification by Whole Genome Sequencing and Joint Analysis.

Smith-Magenis syndrome is a complex neurobehavioral genetic disorder with a broad phenotypic spectrum. While the etiology of SMS is commonly attributed to one-copy interstitial deletion in the 17p11.2 region (90-95% of cases), variants identified by sequence analysis in have also been reported in 5-10% of cases.

Healthcare workers' compliance with COVID-19 prevention and control measures at De Martino Hospital, Mogadishu, Somalia: a cross-sectional study.

Background: Healthcare workers are a high-risk group for COVID-19 and protecting them is crucial for healthcare delivery. Limited studies have explored compliance with infection prevention and control (IPC) practices among Somali healthcare workers. This study aimed to determine compliance with IPC practices among healthcare workers in De Martino Public Hospital, Somalia.

Prior familiarity enhances recognition memory of faces, not just images of faces, when accompanied by conceptual information.

A recent paper reported that recognition discriminability was improved for faces that were familiarized prior to study, but only if that familiarization protocol included conceptual information, like a name (Akan & Benjamin, Journal of Memory and Language, 131, 104,433, 2023). In those experiments, familiarity with each facial identity was gained through exposures to the same facial image prior to study, and memory for each facial identity was tested using the same images across study and test. That design characteristic has a serious constraint on generality, since it is possible that prior conceptual information enhances memory for images (of faces), but not for the representation of the face itself.

Mixed in a World of Truth and Lies: List Composition Moderates the Effects of a Lie Fabrication Manipulation on Memory and Metamemory.

Research has shown that list composition moderates the effects of encoding manipulations on memory performance; differential memory performance is observed at distinct levels of the independent variable in mixed lists, but not in pure lists. The current study aims to investigate the effect of list composition on predicted and actual memory performance using a semantic lie fabrication manipulation. In Experiment 1, participants either told the truth or fabricated a lie in response to a set of general knowledge questions in a mixed-list design, made memory predictions for each response, and received a free recall test.

Whole genome joint analysis reveals ATM:C.1564_1565del variant segregating with Ataxia-Telangiectasia and breast cancer.

ATM gene is implicated in the development of breast cancer in the heterozygous state, and Ataxia-telangiectasia (A-T) in a homozygous or compound heterozygous state. Ataxia-telangiectasia (A-T) is a rare cerebellar ataxia syndrome presenting with progressive neurologic impairment, telangiectasia, and an increased risk of leukemia and lymphoma. Although the role of ATM, separately, in association with A-T and breast cancer is well documented, there is a limited number of studies investigating ATM variants when segregating with both phenotypes in the same family.

Diagnosis of Two Unrelated Syndromes of Prader-Willi and Calpainopathy: Insight from Trio Whole Genome Analysis and Isodisomy Mapping.

Purpose: An investigation for the co-occurrence of two unrelated genetic disorders of muscular dystrophy and Prader-Willi syndrome (PWS) (OMIM#176270) using joint whole genome sequencing (WGS).

Methods: Trio WGS joint analysis was performed to investigate the genetic etiology in a proband with PWS, prolonged muscular hypotonia associated hyperCKemia, and early-onset obesity. The parents were unaffected.

Comparison of Skull Morphometric Characteristics of Simmental and Holstein Cattle Breeds.

This study aimed to reveal the morphological characteristics of pure Holstein and Simmental skulls and to obtain reference values for morphometric analysis. Moreover, 54 skulls from 12- to 14-month-old male Holstein ( = 25) and Simmental ( = 29) cattle were collected from Turkey's Southeastern Anatolia Region between 2023 and 2024. Linear measurements indicated that Holsteins had longer skulls compared to Simmentals.

Social media use as a source of information by acne vulgaris patients.

Background: Social media and internet usage is undeniably high. Misinformation obtained from the internet and wrong treatment methods can cause serious problems in patients with acne vulgaris (AV). In this study, the sociodemographic data of AV patients, their frequency of using the internet as an information source, the relationship between them, and their attitudes and behaviors regarding their disease due to these programs were examined.

Size and shape of the neurocranium of laying chicken breeds.

The neurocranium in birds provides valuable insights into their morphological diversity, including adaptations related to brain size, facial shaping, and environmental factors. This study analyzes the neurocranial shape characteristics and size of chickens with similar genetic backgrounds. By examining the neurocranial shape variation in chickens of the same age and sex, the study aims to understand the factors contributing to morphological diversity within this specific group.

Effects of Peroperative Cold Ischemia Time and Anhepatic Phase in Adult Living Donor Liver Transplant Recipients: Operation Time That is Not Affected by the Anhepatic Phase But is Prolonged by Cold Ischemia Time.

Objective: It was aimed to examine the overall role of cold ischemia time and anhepatic phase durations in terms of peroperative blood transfusion needs, hospital stay conditions and postoperative charges, and survival in recipients.

Material And Methods: One hundred forty-eight adult living donor liver transplant recipients (18 years and older) were included in the study. Whether the anhepatic phase and cold ischemia duration have an effect on the rates of surgery time, blood product transfusion, total hospital and intensive care unit stay, postoperative biliary complications, hepatic vein thrombosis, portal vein thrombosis, early postoperative bleeding, sepsis, and primary graft dysfunction.

Novel de Novo Nonsense Variants in AGO3 and KHSRP: Insights into Global Developmental Delay and Autism Spectrum Disorders through Whole Genome Analysis.

BACKGROUND Neurodevelopmental disorders (NDD) are umbrella disorders that encompass global developmental delay (GDD), intellectual disability, autism spectrum disorders, motor developmental disorders, and sleep disorders. Both GDD and autism spectrum disorder are common and yet clinically and genetically heterogeneous disorders. Despite their high prevalence and the advent of sequencing detection methods, the genomic etiology of GDD and autism spectrum disorder in most patients is largely unknown.

Tumour microenvironment programming by an RNA-RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma.

Patients with IDH-wild-type glioblastomas have a poor five-year survival rate along with limited treatment efficacy due to immune cell (glioma-associated microglia and macrophages) infiltration promoting tumour growth and resistance. To enhance therapeutic options, our study investigated the unique RNA-RNA-binding protein complex LOC-DHX15. This complex plays a crucial role in driving immune cell infiltration and tumour growth by establishing a feedback loop between cancer and immune cells, intensifying cancer aggressiveness.

Prognostic significance of tumor budding, desmoplastic reaction, and lymphocytic infiltration in patients with gastric adenocarcinoma.

Background: Recent studies have shown that the tumor microenvironment significantly influences the behavior of solid tumors. In this context, Accumulated data suggests that pathological evaluation of tumor budding (TB), desmoplastic reaction (DR), and tumor-infiltrating lymphocytes (TILs) may be crucial in determining tumor behavior in the gastrointestinal tract. Regarding gastric adenocarcinoma (GAC), although some results suggest that TB and TILs may be effective in determining the course of the disease, the data do not agree.

Comparison of the efficiency of transcutaneous electrical nerve stimulation and manual therapy in children with cerebral palsy with lower urinary system dysfunction- a randomized prospective trial.

Introduction: Neurological defects in children with cerebral palsy (CP) not only affect their motor skills but also lead to bladder and bowel problems. Although most children with CP have achieved urinary control, more than 50% of cases experience lower urinary tract symptoms (LUTS). Common LUTS complaints observed in CP include delayed toilet training, urinary incontinence, increased frequency of urination, urgency, urinary hesitancy, and recurrent urinary tract infections.