Publications by authors named "Unaiza Ahmad"
Background And Objective: Baricitinib is a JAK1 and JAK2 inhibitor approved for treating active rheumatoid arthritis and atopic dermatitis. Therefore, the authors aim to evaluate the safety and efficacy of once-daily oral Baricitinib 2 mg or 4 mg versus placebo in active SLE patients receiving standard care.
Methods: The authors synthesized randomized controlled studies (RCTs) from MEDLINE, Scopus, EMBASE, PubMed, and Cochrane Library until 20 March 2023.
Article Synopsis
- This study investigates whether sub-lobar resection can be a viable alternative to lobectomy for patients with early-stage non-small cell lung cancer (NSCLC), focusing on those with tumors ≤2 cm.!* -
- After analyzing 27 studies with over 10,000 patients, the results showed that sub-lobar resection had similar overall survival (OS) and disease-free survival (DFS) outcomes compared to lobectomy, although patients in the compromised subgroup had worse DFS with sub-lobar resection.!* -
- Ultimately, while sub-lobar resection did not show overall significant differences in survival or mortality when compared to lobectomy, it indicated poorer outcomes for specific patient groups, particularly those considered compromised.!*
Patients with heart failure (HF) and iron deficiency are at increased risk of adverse clinical outcomes. We searched databases for randomised controlled trials that compared IV iron to placebo, in patients with HF with reduced ejection fraction (HFrEF). A total of 7,813 participants, all having HFrEF with 3,998 receiving IV iron therapy, and 3,815 control recipients were included.
View Article and Find Full Text PDFBackground: Endovascular thrombectomy (ET) efficacy and safety in stroke with a large ischemic core is still inconclusive as this population has been underrepresented in ET randomized controlled trials (RCTs).
Methods: We conducted a systematic review and meta-analysis synthesizing RCTs, which were retrieved by systematically searching: PubMed, Web of Science, SCOPUS, and Cochrane through February 18th, 2023. Our primary outcome was neurological disability measured by the modified Rankin scale (mRS).
Tenecteplase (TNK) is a promising candidate to replace alteplase as the standard of care for acute ischemic stroke (AIS); however, the optimal dosage is still to be investigated. Therefore, we aim to evaluate the safety and efficacy of TNK versus alteplase and to investigate the optimal TNK dosage. A systematic review, pairwise, and network meta-analysis synthesizing randomized controlled trials (RCTs) from WOS, SCOPUS, EMBASE, and PubMed until July 26, 2022.
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- - The study investigates the publishing practices of medical students in Pakistan, highlighting a significant lack of research output among this demographic, with only 6.6% of the surveyed students having published an article.
- - Male students and those in their final year showed higher publication rates, with improved chances for students knowing the importance of research for job prospects and those who received training in writing and submission processes.
- - The results stress the need for educational reforms and support to enhance research participation among medical students, urging authorities to address the barriers they face in publishing.
Vaccines are the best chance to control the pandemic-unless leaders succumb to vaccine nationalism. Vaccine nationalism is a frequent recurrence, especially during a brand-new market distribution. The development of safe and effective COVID-19 vaccines in such a short space of time is a testament to modern scientific abilities.
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