Advancing biomedical applications: antioxidant and biocompatible cerium oxide nanoparticle-integrated poly--caprolactone fibers.

Reactive oxygen species (ROS), which are expressed at high levels in many diseases, can be scavenged by cerium oxide nanoparticles (CeONPs). CeONPs can cause significant cytotoxicity when administered directly to cells, but this cytotoxicity can be reduced if CeONPs can be encapsulated in biocompatible polymers. In this study, CeONPs were synthesized using a one-stage process, then purified, characterized, and then encapsulated into an electrospun poly--caprolactone (PCL) scaffold.

Strategy for Nonenzymatic Harvesting of Cells via Decoupling of Adhesive and Disjoining Domains of Nanostructured Stimulus-Responsive Polymer Films.

The nanostructured polymer film introduces a novel mechanism of nonenzymatic cell harvesting by decoupling solid cell-adhesive and soft stimulus-responsive cell-disjoining areas on the surface. The key characteristics of this architecture are the decoupling of adhesion from detachment and the impermeability to the integrin protein complex of the adhesive domains. This surface design eliminates inherent limitations of thermoresponsive coatings, namely, the necessity for the precise thickness of the coating, grafting or cross-linking density, and material of the basal substrate.

Induced Pluripotent Stem Cell-Derived Corneal Cells: Current Status and Application.

Deficiency and dysfunction of corneal cells leads to the blindness observed in corneal diseases such as limbal stem cell deficiency (LSCD) and bullous keratopathy. Regenerative cell therapies and engineered corneal tissue are promising treatments for these diseases [1]. However, these treatments are not yet clinically feasible due to inadequate cell sources.