In vitro antioxidant, anticancer and in silico studies of polyphenol enriched leaf extract of Asystasia gangetica.

Polyphenols are natural biomolecules known for circumventing several diseases including cancer with little adverse effects. This study aimed to investigate the polyphenol enriched fractions from the leaf extract of Asystasia gangetica for their composition, biological activities such as antioxidant activity, haemolytic effects, and in vitro cytotoxicity against cancer cell lines. LC-MS/MS analysis of the enriched fractions identified a total of 35 distinct polyphenols with caffeic acid, luteolin, apigenin, and protocatechuic acid at higher concentrations.

Intradural extramedullary tuberculoma of the thoracic spine - A rare case report of paraparesis.

Background: Intradural extramedullary tuberculoma of the spinal cord (IETSC) is an extremely rare form of spinal tuberculosis (TB) that is believed to be due to a host's immune reaction against the protein derivatives.

Case Description: A 25-year-old male with human immunodeficiency virus, hepatitis C virus, and disseminated TB on antitubercular therapy for the past 8 months, presented with paraplegia of 2 months duration. When the MRI spine revealed multiple peripheral rim enhancing intradural extramedullary lesions from T6 to T8 and dorsally from T10 to T11, the patient was diagnosed with IETSC.

Effective atomic number of some sugars and amino acids for scattering of (241)Am and (137)Cs gamma rays at low momentum transfer.

In this paper, we report the effective atomic number of some H, C, N and O based sugars and amino acids. These have been determined by using a handy expression which is based on the theoretical angle integrated small angle (coherent+incoherent) scattering cross sections of seven elements of Z≤13 in four angular ranges of (0-4°), (0-6°), (0-8°) and (0-10°)for (241)Am (59.54 keV) and (137)Cs (661.

Molecular and Functional Characterization of RecD, a Novel Member of the SF1 Family of Helicases, from Mycobacterium tuberculosis.

The annotated whole-genome sequence of Mycobacterium tuberculosis revealed the presence of a putative recD gene; however, the biochemical characteristics of its encoded protein product (MtRecD) remain largely unknown. Here, we show that MtRecD exists in solution as a stable homodimer. Protein-DNA binding assays revealed that MtRecD binds efficiently to single-stranded DNA and linear duplexes containing 5' overhangs relative to the 3' overhangs but not to blunt-ended duplex.

Effective atomic number of composite materials for Compton effect in the gamma ray region 280-1115 keV.

In this paper, we report the effective atomic number, Z(eff), of composite materials for Compton effect in the gamma ray region 280-1115 keV based on the theoretically obtained Klein-Nishina scattering cross sections in the angular range 50-100° as well as experimentally measured differential incoherent (Compton) scattering cross sections of some composite materials at three scattering angles of 60°, 80°, and 100°. The Z(eff) values so obtained were found to be both angle and energy independent in the region of interest so that it could be concluded that it is possible to represent such composite materials by a mean atomic number in this region as suggested in earlier reports recently.

Myasthenia gravis: a study from India.

Background: We present the findings from the largest hospital-based studies on myasthenia gravis from India, using data collected over a period of 43 years from the Neurology Department in a tertiary referral center in India.

Objectives: To study the clinical presentation, age at onset, gender distribution, serological status and thymic pathology in patients with myasthenia gravis.

Materials And Methods: A retrospective study was carried out using records of patients with myasthenia gravis from the years 1965 to 2008.