Conjugation with S4 protein transduction domain enhances the immunogenicity of the peptide vaccine against breast cancer.

Although peptide vaccines offer a novel venue for cancer immunotherapy, clinical success has been rather limited. Cell-penetrating peptides, due to their ability to translocate through the cell membrane, could be conjugated to the peptide vaccine to2 enhance therapeutic efficiency. The S4 transduction domain of the shaker-potassium channel was conjugated to mammaglobin-A (MamA) immunodominant epitope (MamA2.

Chronic High-Salt Diet Activates Tumor-Initiating Stem Cells Leading to Breast Cancer Proliferation.

Several chronic inflammatory diseases have been linked to high-salt (HS) diets. Chronic inflammation is an established causative hallmark of cancer. However, a direct role of HS diets in tumorigenesis is yet to be defined.

Genomic Features of Homologous Recombination Deficiency in Breast Cancer: Impact on Testing and Immunotherapy.

Genomic instability is one of the well-established hallmarks of cancer. The homologous recombination repair (HRR) pathway plays a critical role in correcting the double-stranded breaks (DSB) due to DNA damage in human cells. Traditionally, the genes in the HRR pathway have been tested for their association with breast cancer.

Efficacy of Autoinoculation in Treatment of Multiple Viral Warts - A Single Arm Study.

Objective: To test the effectiveness of autoinoculation of a wart in patients with multiple viral warts.

Study Design: An experimental study.

Place And Duration Of Study: Department of Dermatology, Pak Emirates Military Hospital (PEMH), Rawalpindi, from February 2021 to February 2022.

Analysis of aerosol liquid water content and its role in visibility reduction in Delhi.

Aerosols undergo significant changes due to water uptake under high RH conditions, leading to changes in physical, optical, and chemical properties. Detailed assessment and investigation are needed to understand better aerosol liquid water content (ALWC) characteristics in highly polluted regions like Delhi. Therefore, in this study, we examined the mass concentration and the factors governing the ALWC associated with PM in Delhi for two winters (Dec 2019 to Jan 2020 and Dec 2020 to Feb 2021) using the real-time measurements of NR-PM from Aerodyne aerosol chemical speciation monitor (ACSM) and the application of thermodynamic modeling (ISORROPIA II).

Pharmacy services during COVID-19 pandemic: experience from a tertiary care teaching hospital in Pakistan.

The coronavirus disease 19 (COVID-19) is rapidly spreading across the world. Pharmacy services play a vital role in public health in preventing and containing the COVID-19 pandemic. All over the world, especially in the developed countries pharmacists have responded smartly and speedily for public health, such as establishing professional protective and service guidance for pharmacy staff and services, creating and updating drug formularies, addressing the issues of drug shortages, providing public education for prevention and management of infection, contributing in drug evaluation and clinical trials.

Neonatal fluid and electrolytes profile effect on amphotericin B associated nephrotoxicity in neonatal tertiary care unit of Karachi-Pakistan.

Objectives: Amphotericin-B (d-AmB) has a broader anti-fungal spectrum and is used for neonatal invasive-fungal-infections especially invasive-candidiasis (IC). To prevent d-AmB-induced nephrotoxicity, renal protective effect of fluid and electrolyte management has been established among adults; in this study, the authors determined this effect among neonates.

Methods: In this retrospective cohort study, the authors reviewed neonatal medical records, admitted to neonatal intensive care unit and received d-AmB therapy.

Efficacy of colistin in multidrug-resistant neonatal sepsis: experience from a tertiary care center in Karachi, Pakistan.

Objective: Infections with multidrug-resistant organisms (MDROs) such as Gram-negative bacteria have high morbidity and mortality with limited treatment options. Colistin, an antibiotic active against MDRO, was rarely used due to frequent adverse effects, but its use has now been recommended among adults. In this study, we determined the efficacy of colistin for the treatment of sepsis in neonates.