Mortality Risk Among Patients Hospitalized Primarily for COVID-19 During the Omicron and Delta Variant Pandemic Periods - United States, April 2020-June 2022.

The risk for COVID-19-associated mortality increases with age, disability, and underlying medical conditions (1). Early in the emergence of the Omicron variant of SARS-CoV-2, the virus that causes COVID-19, mortality among hospitalized COVID-19 patients was lower than that during previous pandemic peaks (2-5), and some health authorities reported that a substantial proportion of COVID-19 hospitalizations were not primarily for COVID-19-related illness,* which might account for the lower mortality among hospitalized patients. Using a large hospital administrative database, CDC assessed in-hospital mortality risk overall and by demographic and clinical characteristics during the Delta (July-October 2021), early Omicron (January-March 2022), and later Omicron (April-June 2022) variant periods among patients hospitalized primarily for COVID-19.

Cardiac Complications After SARS-CoV-2 Infection and mRNA COVID-19 Vaccination - PCORnet, United States, January 2021-January 2022.

Cardiac complications, particularly myocarditis and pericarditis, have been associated with SARS-CoV-2 (the virus that causes COVID-19) infection (1-3) and mRNA COVID-19 vaccination (2-5). Multisystem inflammatory syndrome (MIS) is a rare but serious complication of SARS-CoV-2 infection with frequent cardiac involvement (6). Using electronic health record (EHR) data from 40 U.

Comparing the historical limits method with regression models for weekly monitoring of national notifiable diseases reports.

To compare the performance of the standard Historical Limits Method (HLM), with a modified HLM (MHLM), the Farrington-like Method (FLM), and the Serfling-like Method (SLM) in detecting simulated outbreak signals. We used weekly time series data from 12 infectious diseases from the U.S.

Coding of Electronic Laboratory Reports for Biosurveillance, Selected United States Hospitals, 2011.

Objective Electronic laboratory reporting has been promoted as a public health priority. The Office of the U.S.

Practical comparison of aberration detection algorithms for biosurveillance systems.

National syndromic surveillance systems require optimal anomaly detection methods. For method performance comparison, we injected multi-day signals stochastically drawn from lognormal distributions into time series of aggregated daily visit counts from the U.S.

Summary of notifiable diseases--United States, 2012.

The Summary of notifiable diseases--United States, 2012 contains the official statistics, in tabular and graphic form, for the reported occurrence of nationally notifiable infectious diseases in the United States for 2012. Unless otherwise noted, the data are final totals for 2012 reported as of June 30, 2013. These statistics are collected and compiled from reports sent by state health departments and territories to the National Notifiable Diseases Surveillance System (NNDSS), which is operated by CDC in collaboration with the Council of State and Territorial Epidemiologists (CSTE).

Cancer incidence rates and trends among children and adolescents in the United States, 2001-2009.

Objectives: Cancer continues to be the leading disease-related cause of death among children and adolescents in the United States. More current information is needed to describe recent cancer trends and identify demographic and geographic variations.

Methods: We analyzed data from the National Program of Cancer Registries and Surveillance, Epidemiology, and End Results statewide registries representing 94.

Completeness of reporting of race and ethnicity data in the nationally notifiable diseases surveillance system, United States, 2006-2010.

Context: During 1994-1997, approximately 70% and 60% of the cases of conditions reported to the National Notifiable Diseases Surveillance System included persons of known race and ethnicity, respectively. A major goal of the Healthy People 2020 initiative is to eliminate health disparities.

Objective: To describe trends in the completeness of race and ethnicity in case reports of the National Notifiable Diseases Surveillance System during 2006-2010.

Prostate cancer deaths and incident cases among American Indian/Alaska Native men, 1999-2009.

Objectives: We linked databases to improve identification of American Indians/Alaska Natives (AI/ANs) in determining prostate cancer death and incidence rates.

Methods: We linked prostate cancer mortality and incidence data with Indian Health Service (IHS) patient records; analyses focused on residents of IHS Contract Health Service Delivery Area (CHSDA) counties. We calculated age-adjusted incidence and death rates for AI/AN and White men for 1999 to 2009; men of Hispanic origin were excluded.

Syndromic surveillance in an ICD-10 world.

The Centers for Disease Control and Prevention's BioSense program is an integrated national public health surveillance system that uses electronic medical record (EMR) data to provide situational awareness for all-hazard health-related events. Because the system leverages International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) coded data from EMRs for syndromic surveillance, the upcoming Health and Human Services-mandated transition from ICD-9-CM to ICD-10-CM will have a significant impact. To translate across the two encoding systems, we developed a Mapping Reference Table (MRT) for the ICD-9/10 transition.

Evaluating factors associated with unknown SEER Summary Stage 2000 derived from collaborative stage at central registry level.

Background: Cancer stage is critical for treatment planning and assessing disease prognosis. The percentage of unknown staged cancer cases varies considerably across state cancer registries; factors contributing to the variations in unknown stage have not been reported in the literature before. The purpose of this study was to examine whether these variations were influenced by demographic and/or clinical factors as well as the type of reporting facility.

Descriptive epidemiology of malignant and nonmalignant primary spinal cord, spinal meninges, and cauda equina tumors, United States, 2004-2007.

Background: Primary tumors of the spinal cord, spinal meninges, and cauda equina are relatively rare, and a paucity of population-based data exist on tumors in these sites. This study intends to augment the current literature by examining incidence of these tumors on a national level.

Methods: Data from central cancer registries in the National Program of Cancer Registries (NPCR) and Surveillance, Epidemiology, and End Results (SEER) programs for 2004-2007 (covering 99.

Anatomic distribution of malignant melanoma on the non-Hispanic black patient, 1998-2007.

Objectives: To provide a population-based description of the anatomic distribution of melanoma among non-Hispanic black patients and to explore how characteristics of this distribution relate to the etiologies previously reported for both white and black patients.

Design: Cross-sectional, retrospective.

Setting: United States, January 1, 1998, through December 31, 2007.

Recent trends in prostate cancer testing and incidence among men under age of 50.

Background: Information on prostate cancer testing and incidence among men under age 50 is scant. This study aims to describe trends of prostate cancer testing and incidence by demographic and clinical characteristics and identify potential correlations between prostate cancer testing and incidence.

Methods: We examined prostate cancer testing and incidence rates among American men under age of 50 using data from the Behavioral Risk Factor Surveillance System (2002, 2004, 2006, and 2008) and data from the National Program of Cancer Registries and Surveillance, Epidemiology, and End Results programs (2001-2006).

Melanoma survival in the United States, 1992 to 2005.

Background: Population-based data on melanoma survival are important for understanding the impact of demographic and clinical factors on prognosis.

Objective: We describe melanoma survival by age, sex, race/ethnicity, stage, depth, histology, and site.

Methods: Using Surveillance, Epidemiology, and End Results data, we calculated unadjusted cause-specific survival up to 10 years from diagnosis for 68,495 first primary cases of melanoma diagnosed from 1992 to 2005.

Association of cutaneous melanoma incidence with area-based socioeconomic indicators-United States, 2004-2006.

Background: Socioeconomic status (SES) has been associated with melanoma incidence and outcomes. Examination of the relationship between melanoma and SES at the national level in the United States is limited. Expanding knowledge of this association is needed to improve early detection and eliminate disparities.

Association between cutaneous melanoma incidence rates among white US residents and county-level estimates of solar ultraviolet exposure.

Background: Recent US studies have raised questions as to whether geographic differences in cutaneous melanoma incidence rates are associated with differences in solar ultraviolet (UV) exposure.

Objectives: We sought to assess the association of solar UV exposure with melanoma incidence rates among US non-Hispanic whites.

Methods: We assessed the association between county-level estimates of average annual solar UV exposure for 1961 to 1990 and county-level melanoma incidence rates during 2004 to 2006.

Trends in endometrial cancer incidence rates in the United States, 1999-2006.

Background: Risk factors for endometrial cancer, such as hormone replacement therapy (HRT) and obesity, have changed significantly in the last decade. We investigated trends in endometrial cancer histologic subtypes on a national level during 1999-2006.

Methods: Data covering 88% of the U.

Annual report to the nation on the status of cancer, 1975-2007, featuring tumors of the brain and other nervous system.

Background: The American Cancer Society, the Centers for Disease Control and Prevention (CDC), the National Cancer Institute, and the North American Association of Central Cancer Registries (NAACCR) collaborate annually to provide updated information on cancer occurrence and trends in the United States. This year's report highlights brain and other nervous system (ONS) tumors, including nonmalignant brain tumors, which became reportable on a national level in 2004.

Methods: Cancer incidence data were obtained from the National Cancer Institute, CDC, and NAACCR, and information on deaths was obtained from the CDC's National Center for Health Statistics.

Comparisons of directly coded SEER Summary Stage 2000 and Collaborative Staging Derived SEER Summary Stage 2000.

This study assessed comparability of the directly coded Summary Stage 2000 and the Collaborative Stage (CS) Derived Summary Stage 2000 (SS2000) using 2001-2004 data from 40 population-based cancer registries in the United States that met the high quality criteria. The likelihood ratio test was employed to determine whether stage differences between 2003 (pre-CS) and 2004 (CS) were attributable to 2001-2004 linear trends, decreases in percentage of unknown stage cases, or both. Statistically significant differences in stage distribution between 2003 and 2004 were observed for 30 out of the 34 cancer sites.

The changing incidence of in situ and invasive ductal and lobular breast carcinomas: United States, 1999-2004.

Background: National incidence rates for lobular and ductal breast cancers have not been available previously. Evidence suggests that the increased risk of breast cancer associated with combined hormone replacement therapy use is higher for invasive lobular cancers (ILC) than for invasive ductal cancers (IDC). This study provides U.

Evaluating quality of census tract data in the NPCR dataset.

Background: Knowledge of data quality is essential for accurate interpretation and use of cancer data by cancer control and prevention programs and researchers.

Objective: To assess the quality of census tract information in the Centers for Disease Control and Prevention's (CDC) National Program of Cancer Registries (NPCR) dataset. This assessment will guide analyses using census tract information from the NPCR dataset.

Comparative evaluation of uterine cancer staging data using two different staging systems, 2001-2005.

Objective: This study compares directly coded Summary Stage 2000 (SS2000) with that of Collaborative Stage (CS) Derived Summary Stage 2000 (DeSS2000) for cases of uterine cancer diagnosed in the years 2001-2005 using population-based cancer registry data.

Methods: Data included in this study were from central cancer registries that participated in the Surveillance, Epidemiology, and End Results (SEER) Program or the National Program of Cancer Registries (NPCR) and met data quality criteria for 2001-2005 covering approximately 80% of the US population. The data for diagnosis years 2001-2003 (pre-CS) were compared with those for diagnosis years 2004-2005 (post-CS) to review any shifts in staging between the pre- and post-CS years.