Minor Cannabinoids as Inhibitors of Skin Inflammation: Chemical Synthesis and Biological Evaluation.

Despite millennia of therapeutic plant use, deliberate exploitation of 's diverse biomedical potential has only recently gained attention. Bioactivity studies focus mainly on cannabidiol (CBD) and tetrahydrocannabinol (THC) with limited information about the broader cannabinome's "minor phytocannabinoids". In this context, our research targeted the synthesis of minor cannabinoids containing a lateral chain with 3 or 4 carbon atoms, focusing on cannabigerol (CBG) and cannabichromene (CBC) analogues.

Cannabidiol as Self-Assembly Inducer for Anticancer Drug-Based Nanoparticles.

Cannabidiol (CBD) is a biologically active compound present in the plants of the family, used as anticonvulsant, anti-inflammatory, anti-anxiety, and more recently, anticancer drug. In this work, its use as a new self-assembly inducer in the formation of nanoparticles is validated. The target conjugates are characterized by the presence of different anticancer drugs (namely -desacetyl thiocolchicine, podophyllotoxin, and paclitaxel) connected to CBD through a linker able to improve drug release.

Convenient Preparation and Spectroscopic Characterization of 7-Hydroxymatairesinol.

The preparation of 7-HMR (-hydroxymatairesinol) is reported by: (a) NaBH kinetic reduction of 7/7 diastereomeric mixture; and (b) epimerization of the C7 hydroxyl group by Mitsunobu reaction and subsequent ester hydrolysis. The availability of highly pure target compound (7-HMR) made it possible to confirm the structure of the target compound and to complete the full spectroscopic characterization.