Effect of in situ mixed micellization of ester-functionalized gemini surfactant at different pHs on solubilization and cosolubilization of various polycyclic aromatic hydrocarbons of varying hydrophobicities.

A pH controlled cleavability unfolds the 3-in-1 surfactant feature of an ester-bonded gemini surfactant, 2, 2'-[(oxybis (ethane-1,2-diyl))bis (oxy)]bis (N-hexadecyl-N,Ndimethyl-2-oxoethanaminium) dichloride (C16-C4O2-C16), by reinforcing in-situ mixed micellization between cleaved components at non-neutral pH (pH 3,12). The triplicity is assigned to two mixed-micelle variants at pH 3 and pH 12 besides the unhydrolyzed C16-C4O2-C16 at pH 7. The pH-controlled aggregation of such trichotomic surfactant dramatically enhances the micellar solubilization/cosolubilization of PAHs viz.

Bergenia stracheyi extract-based hybrid hydrogels of biocompatible polymers with good adhesive, stretching, swelling, self-healing, antibacterial, and antioxidant properties.

An ultra-stretchable, quickly self-healable, adhesive hydrogel with efficient anti-oxidant and anti-bacterial activities makes it potential wound dressing material, particularly in healing skin wounds. However, it is highly challenging to prepare such hydrogels with a facile and efficient material design. Given this, we opine the synthesis of medicinal plant Bergenia stracheyi extract-loaded hybrid hydrogels of biocompatible and biodegradable polymers like Gelatin, Hydroxypropyl cellulose, and Polyethylene glycol with acrylic acid via in situ free radical polymerization reaction.

Effect of nanoemulsion-loaded hybrid biopolymeric hydrogel beads on the release kinetics, antioxidant potential and antibacterial activity of encapsulated curcumin.

Nanoemulsion encapsulated in the hydrogel beads are important entrants for loading hydrophobic active ingredients for enhancing their bioavailability and biological activities relevant in the pharmaceutical, food and cosmetic industries. Herein, we report the formulation of curcumin-loaded nanoemulsion encapsulated in ionotropic hybrid hydrogel beads of alginate, chitosan, gelatin and polyethylene oxide for effective delivery of curcumin. The release behaviour in simulated gastric and intestinal fluids (SGF and SIF) at 37 °C showed faster release in SGF which could be explained on the basis of mesh size, the extent of hydration and the complexation of the curcumin with the Ca ions present within the hydrogel network.