Advanced AI and ML frameworks for transforming drug discovery and optimization: With innovative insights in polypharmacology, drug repurposing, combination therapy and nanomedicine.

Artificial Intelligence (AI) and Machine Learning (ML) are transforming drug discovery by overcoming traditional challenges like high costs, time-consuming, and frequent failures. AI-driven approaches streamline key phases, including target identification, lead optimization, de novo drug design, and drug repurposing. Frameworks such as deep neural networks (DNNs), convolutional neural networks (CNNs), and deep reinforcement learning (DRL) models have shown promise in identifying drug targets, optimizing delivery systems, and accelerating drug repurposing.

Highly selective and reusable nanoadsorbent based on FeO-embedded sodium alginate-based hydrogel for cationic dye adsorption: Adsorption interpretation using multiscale modeling.

This study aims to develop a stable and efficient magnetic nanocomposite hydrogel (MNCH) for selective removal of methylene blue (MB) and crystal violet (CV). MNCHs with different FeO contents (0-9 wt%) were synthesized following graft co-polymerization method using sodium alginate, acrylamide, itaconic acid, ammonium persulfate and N,N-methylene bisacrylamide. Among them, MNCH, with 5 wt% FeO, showed highest removal efficiency (>95 %).

Enhanced Fault Diagnosis in Milling Machines Using CWT Image Augmentation and Ant Colony Optimized AlexNet.

A method is proposed for fault classification in milling machines using advanced image processing and machine learning. First, raw data are obtained from real-world industries, representing various fault types (tool, bearing, and gear faults) and normal conditions. These data are converted into two-dimensional continuous wavelet transform (CWT) images for superior time-frequency localization.

Assessment of field performance and bruchid resistance during seed storage of a genetically modified cowpea expressing the alpha-amylase inhibitor 1 protein from common bean.

Introduction: The cowpea weevil, Fab., is the most economically important storage pest of cowpeas, causing up to 100 percent grain losses within six months of storage. To sustainably resist weevil damage, the cowpea cultivar IT86D-1010 was genetically modified via -mediated transformation to produce event CSI-32, which expresses the kidney bean alpha-amylase inhibitor 1 (αAI-1) protein exclusively in the seed, providing suppression of weevil development.

THE EFFECT OF PRE-MEDICATION WITH ORAL STEROIDS ON INTRA-OPERATIVE BLEEDING IN PATIENTS WITH CHRONIC RHINOSINUSITIS UNDERGOING FUNCTIONAL ENDOSCOPIC SINUS SURGERY.

Background: An inflammation of the nasal and paranasal sinus mucosa that lasts longer than three months is known as chronic rhinosinusitis. When corticosteroids and other medicinal treatments fail to relieve a patient's symptoms, then functional endoscopic sinus surgery (FESS) is a commonly performed procedure to alleviate the symptoms. The aim of the study was to evaluate the impact of oral steroids given prior to surgery on intraoperative bleeding in patients having functional endoscopic sinus surgery for chronic rhinosinusitis.

COMPARISON OF EFFICACY OF NSAIDS WITH INTRA- ARTICULAR INJECTION OF CORTICOSTEROIDS IN PATIENTS OF TEMPOROMANDIBULAR DISORDER WITH INTERNAL DISC DISPLACEMENT WITHOUT REDUCTION.

Background: Temporomandibular disorders (TMD) are a diverse set of musculoskeletal and neuromuscular problems involving the temporomandibular joint complex and surrounding muscles 1. TMD prevalence has varied from one location to the next, with estimates ranging from 6 to 68 % in various types Objectives were to compare the efficacy of NSAIDs with intra-articular injection of corticosteroids in patients suffering from temporomandibular disorders (TMD) due to disc displacement without reduction in terms of mean pain score and mean mouth opening. This Randomized control trial was conducted at the Oral & Maxillofacial Surgery Department, PMC Dental institute, Faisalabad Medical University, Faisalabad, Pakistan, from 6th April 2018 to 6th April 2019.

Advanced Bearing-Fault Diagnosis and Classification Using Mel-Scalograms and FOX-Optimized ANN.

Accurate and reliable bearing-fault diagnosis is important for ensuring the efficiency and safety of industrial machinery. This paper presents a novel method for bearing-fault diagnosis using Mel-transformed scalograms obtained from vibrational signals (VS). The signals are windowed and pass through a Mel filter bank, converting them into a Mel spectrum.

Correlates of Food Contamination by Heavy Metals in Northwest Nigeria.

Background: The increasing cases of chronic kidney disease is a global public health concern. The potential link between consumption of food contaminated with heavy metals and development of end stage renal disease is becoming an emerging challenge. This study aimed to identify heavy metal contaminants in food and environmental risk factors for development of chronic kidney disease in Nigeria.

A comparative study of food safety knowledge among mobile food vendors and canteen food handlers in markets in Kano Metropolis, Northwest Nigeria.

Introduction: foodborne diseases are an emerging public health challenge due to the global increase in vended food. This study aimed to compare food safety knowledge among mobile and canteen food handlers in Kano metropolis.

Methods: a comparative cross-sectional design was used to study 310 mobile food vendors and 310 canteen food handlers selected using a multi-stage sampling technique.

Development of novel osteoarthritis therapy by targeting AMPK-β-catenin-Runx2 signaling.

Osteoarthritis (OA) is a debilitating chronic joint disease affecting large populations of patients, especially the elderly. The pathological mechanisms of OA are currently unknown. Multiple risk factors are involved in OA development.

PATHWAYS TO CARE AMONG PATIENTS WITH MENTAL ILLNESS AT USMANU DANFODIYO UNIVERSITY TEACHING HOSPITAL, SOKOTO, NIGERIA.

Background: The first line of care is a paramount stage in the management of the mentally ill persons. In Nigeria, traditional and faith-based healers compete with medical professionals in providing care.

Aim: Pathway to care among patients with Mental Illness at Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria.

DEPRESSION AS A PREDICTOR OF OPIOID USE DISORDER IN SICKLE CELL DISEASE PATIENTS.

Background: Sickle cell disease (SCD) is highly prevalent in Africa, especially in Nigeria, the most populous country, and is associated with a high mortality rate. Depression, common among individuals with SCD, correlates with increased pain intensity and opioid misuse, leading to poorer outcomes and diminished quality of life in these patients.

Aim: To determine whether major depressive disorder is a predictor of opioid use disorder among patients with sickle cell disease.

Evaluating the implementation of the National Primary Health Care Development Agency (NPHCDA) gateway for the Basic Healthcare Provision Fund (BHCPF) across six Northern states in Nigeria.

Background: This evaluation research utilized both qualitative and quantitative methods to assess the implementation of the National Primary Health Care Development Agency (NPHCDA) gateway of the Basic Health Care Provision Fund (BHCPF) across six states in Northern Nigeria: Bauchi, Borno, Kaduna, Kano, Sokoto, and Yobe.

Methods: This was a mixed-method research that utilized longitudinal surveys and Key informant interviews to gather information about the implementation status of the BHCPF-NPHCDA gateway. Checklists were developed based on the BHCPF's national guidelines to gather quantitative data, while simple open-ended questionnaires were used to collect qualitative data from the state BHCPF Program Implementation Unit (PIU) focal persons as key informants.

COMPARATIVE ASSESSMENT OF PERCEIVED QUALITY OF ANTENATAL SERVICES AMONG INSURED AND UNINSURED PREGNANT WOMEN ATTENDING ANTENATAL CLINIC IN A TERTIARY HEALTH INSTITUTION, IN SOKOTO, NIGERIA.

Introduction: Access to quality antenatal care (ANC) is essential in reducing high maternal morbidity and mortality, especially in resource-poor countries. One way of ensuring financial accessibility to high-quality ANC services is through health insurance. This study assessed the perceived quality of services among insured and uninsured pregnant women attending the ANC at a tertiary health institution in Sokoto, Nigeria.

Assessing the Effectiveness of a Short Injectable Treatment Regimen for Multidrug-Resistant Tuberculosis: Clinical Outcomes in Khyber Pakhtunkhwa.

Background The currently recommended treatment regimens for multidrug-resistant tuberculosis (MDR-TB) are complex, costly, prolonged (lasting at least 20 months), and often poorly tolerated. The objective of this study was to evaluate the effectiveness of the shorter treatment regimen (STR) for treating patients with MDR-TB in Khyber Pakhtunkhwa. Methodology The present study was a case series conducted at the Programmatic Management of Drug Resistant TB Unit, Lady Reading Hospital (PMDT-LRH), Khyber Pakhtunkhwa, Pakistan.

Creating a biomedical knowledge base by addressing GPT inaccurate responses and benchmarking context.

We created GNQA, a generative pre-trained transformer (GPT) knowledge base driven by a performant retrieval augmented generation (RAG) with a focus on aging, dementia, Alzheimer's and diabetes. We uploaded a corpus of three thousand peer reviewed publications on these topics into the RAG. To address concerns about inaccurate responses and GPT 'hallucinations', we implemented a context provenance tracking mechanism that enables researchers to validate responses against the original material and to get references to the original papers.

Recurrent fungal endocarditis of the aortic valve: A challenging clinical scenario.

Key Clinical Message: Fungal endocarditis is a rare but potentially fatal infection with significant diagnostic and management challenges. Antifungal therapy and surgical debridement are the preferred treatments in these cases. Antimicrobial therapy with multiple antifungal agents may be required in high-risk patients presenting with prolonged fever suspected of having fungal endocarditis.

Effective Identification and Highly Sensitive Quantification of Fructo-oligosaccharide Isomers with BiSe Nanosheet-Assisted Laser Desorption Ionization Mass Spectrometry.

The growing interest in fructo-oligosaccharides (FOSs) necessitates the effective monitoring of product quality. Identifying and quantifying FOS isomers from the same sources are challenging. Here, we report a new method using BiSe nanosheets as the matrix for matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS), achieving effective differentiation of oligosaccharide isomers through MALDI-MS/MS.

evaluation of favipiravir-associated potential new drugs against polymerase enzyme of SARS-CoV-2.

Millions of lives have been lost to the deadly SARS-CoV-2 virus. Vaccines and antiviral drugs are essential scientific tools in combating viral infections. This study focused on the RdRp inhibitor favipiravir, exploring new analogs by substituting the fluorine atom on the pyrazine ring with both homocyclic and heterocyclic moieties.