Publications by authors named "Umar Ebrahimsa"
Article Synopsis
- Since May 2022, there has been a notable rise in human monkeypox virus cases, particularly through human-to-human transmission in nonendemic countries, prompting a study to better understand the characteristics of affected patients.
- The study included 140 patients, half of whom tested positive for monkeypox; findings showed that the majority of positive cases were cis-males who identified as gay or bisexual, with lymphadenopathy and specific rash locations linked to higher positivity rates.
- The data suggests a need for targeted management strategies in the LGBTQ+ community and supports the use of virtual ward follow-ups in addressing the outbreak.
Virus diversity and escape from immune responses are the biggest challenges to the development of an effective vaccine against HIV-1. We hypothesized that T-cell vaccines targeting the most conserved regions of the HIV-1 proteome, which are common to most variants and bear fitness costs when mutated, will generate effectors that efficiently recognize and kill virus-infected cells early enough after transmission to potentially impact on HIV-1 replication and will do so more efficiently than whole protein-based T-cell vaccines. Here, we describe the first-ever administration of conserved immunogen vaccines vectored using prime-boost regimens of DNA, simian adenovirus and modified vaccinia virus Ankara to uninfected UK volunteers.
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