Publications by authors named "Umar Abdullahi Zakariya"
Article Synopsis
- Butyrylcholinesterase (BChE) plays a crucial role in the progression of Alzheimer's disease, as its normal function is disrupted in patients with advanced AD, impacting cholinergic neurotransmission.
- Research utilized enzyme kinetic studies, molecular modeling, and protein-ligand interactions to investigate how methylrosmarinate interacts with BChE, revealing that it binds effectively in BChE's active site and stabilizes interactions with various subsites.
- The study found that methylrosmarinate significantly inhibits BChE, with specific kinetic values indicating it could be a promising inhibitor, although the exact mechanisms of this inhibition in relation to various disease conditions need further research.
