Comparative structural and functional analysis of the PGU1 protein from with other .

An endo-poly-galacturonase (PGU1) gene product is responsible for the pectolytic activity in Saccharomyces bayanus. Therefore, it is of interest to document the comparative structural and functional analysis of the PGU1 protein from Saccharomyces bayanus with those in other Saccharomyces related species. The molecular docking analyses of pectin with the different homology models of PGU1 protein from several Saccharomyces species are reported.

Isolation of bioactive compounds from lichen Parmelia sulcata and evaluation of antimicrobial property.

Background: Lichens were used as an ailment in the traditional medicine for treating various disorders for centuries. Since there is less evidence in the literature about the medicinal property of Parmelia sulcata (P. sulcata), we made a pioneer attempt to explore the antioxidant and antimicrobial properties of lichens.

Ethnopharmacological Applications of Mango ( L.) Peel - A Review.

Background: Mango peel is a major by-product of mango (Mangifera Indica L.) fruit that belongs to the Anacardiaceae family. It is a tropical or subtropical fruit and is a potent source of polyphenolic contents.

Designing, docking and molecular dynamics simulation studies of novel cloperastine analogues as anti-allergic agents: homology modeling and active site prediction for the human histamine H1 receptor.

The present study predicts a three-dimensional model for the histamine H1 receptor and the design of antihistamine inhibitors using cloperastine as the core molecule by docking studies. In this work, we predicted a three-dimensional structure of the histamine H1 receptor using the MODELLER9V7 software. The protein structure was developed based on the crystal structure of the histamine H1 receptor, the lysozyme chimera of T4 (PDB ID: 3RZE_A) target collected from the PDB data bank.

In Silico Studies on Anti-Stress Compounds of Ethanolic Root Extract of Hemidesmus indicus L.

Background: Alternative medicine is available for those diseases which cannot be treated by conventional medicine. Ayurveda and herbal medicines are important alternative methods in which the treatment is done with extracts of different medicinal plants. This work is concerned with the evaluation of anti-stress bioactive compounds from the ethanolic root extract of Hemidesmus indicus.

Lichen Parmelia sulcata mediated synthesis of gold nanoparticles: an eco-friendly tool against Anopheles stephensi and Aedes aegypti.

The gold nanoparticles (AuNPs) were synthesized using the lichen Parmelia sulcata extract (PSE) and characterized. The peaks of ultraviolet spectrophotometer and Fourier transmission infrared confirmed the formation of nanoparticles and the bioactive compounds of the lichen being responsible for reducing and capping of the particles. The face-centered cubic particles were determined by XRD peaks at 111, 200, 220, and 311.

Analysis of Chemical Signatures of Alkaliphiles using Fatty Acid Methyl Ester Analysis.

Background: Fatty acids occur in nearly all living organisms as the important predominant constituents of lipids. While all fatty acids have essentially the same chemical nature, they are an extremely diverse group of compounds.

Materials And Methods: To test the hypothesis, fatty acids of alkaliphiles isolates, SVUNM4, SVUNM8, SVUNM9, and SVUNM11, were characterized compared using gas chromatography-mass spectrometry (GC-MS) analysis.

Incidence of cardiovascular diseases and associated risk factors among subjects with type 2 diabetes - an 11-year follow up study.

Aims: This study was planned to assess the development of cardiovascular disease (CVD) events over an 11-year period and to identify the associated risk factors that could predict the onset of CVD among subjects with type 2 diabetes.

Methods: Retrospective data of 249 patients (M:F 149:100) with type 2 diabetes, from a cohort of 7800 patients, attending a tertiary care center for diabetes from January 2000 to December 2011 were retrieved and analyzed for this study. Sociodemographic and habitual risk factors, baseline diabetes duration, HbA1c and time of onset of CVD and its risk factors were collected from case records.