Publications by authors named "Umakar Reddy"
Article Synopsis
- Maternal under-nutrition, particularly vitamin B12 restriction, negatively impacts the growth and metabolic health of offspring, as shown in a study with Wistar rats.
- Rehabilitating restricted mothers from conception led to significant improvements in their offspring's body composition and glucose metabolism, highlighting the critical role of vitamin B12 during pregnancy and lactation.
- Offspring of mothers who were only rehabilitated post-partum showed only partial recovery, suggesting that early nutritional intervention is crucial for mitigating adverse effects of maternal deficiency.
Introduction: Altered angiogenesis has been implicated in the pathogenesis of various pregnancy complications, particularly preeclampsia. At present, there is a lack of data on the possible role of angiogenesis and its molecular mechanism in preterm pregnancy. We have previously reported reduced placental global DNA methylation levels in preterm pregnancy.
View Article and Find Full Text PDFBackground: Preeclampsia, a pregnancy complication of placental origin is associated with altered expression of angiogenic factors and their receptors. Recently, there is considerable interest in understanding the role of adverse intrauterine conditions in placental dysfunction and adverse pregnancy outcomes. Since we have observed changes in placental global DNA methylation levels in preeclampsia, this study was undertaken to examine gene promoter CpG methylation and expression of several angiogenic genes.
View Article and Find Full Text PDFBackground: Type 2 diabetes is a global problem that is increasingly prevalent in low and middle income countries including India, and is partly attributed to increased urbanisation. Genotype clearly plays a role in type 2 diabetes susceptibility. However, the role of DNA methylation and its interaction with genotype and metabolic measures is poorly understood.
View Article and Find Full Text PDFDNA methylation is crucial for gene regulation and maintenance of genomic stability. Rat has been a key model system in understanding mammalian systemic physiology, however detailed rat methylome remains uncharacterized till date. Here, we present the first high resolution methylome of rat liver generated using Methylated DNA immunoprecipitation and high throughput sequencing (MeDIP-Seq) approach.
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