Publications by authors named "Umadevi Nagaraja"
Article Synopsis
- Increased susceptibility to genital herpes in medroxyprogesterone-treated mice may indicate heightened risk for HIV, making it a useful model for testing preexposure prophylaxis safety.
- Development of a 0.3% tenofovir disoproxil fumarate (TDF) gel was tested in mice to evaluate its effectiveness compared to placebo and a higher concentration gel, showing significant protection against HSV-2 disease.
- The study found that the TDF gel was safe, did not increase HSV susceptibility, and demonstrated greater protection than a 1% tenofovir gel, supporting further advancement toward clinical trials for a TDF intravaginal ring.
Topical preexposure prophylaxis interrupts HIV transmission at the site of mucosal exposure. Intermittently dosed vaginal gels containing the HIV-1 reverse transcriptase inhibitor tenofovir protected pigtailed macaques depending on the timing of viral challenge relative to gel application. However, modest or no protection was observed in clinical trials.
View Article and Find Full Text PDFIn light of the increasing worldwide AIDS pandemic, there is a continuing need to develop new prevention strategies to inhibit the transmission of HIV-1. In the absence of a successful vaccine, topical microbicides represent the best strategies to reduce the epidemic. Following the success of HIV therapeutic cocktail strategies, combinations of microbicides including nucleotide reverse transcriptase inhibitors (NtRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) may offer significant protection from infection over single agents.
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