The article highlights omics-based interventions in sorghum to combat food and nutritional scarcity in the future. Sorghum with its unique ability to thrive in adverse conditions, has become a tremendous highly nutritive, and multipurpose cereal crop. It is resistant to various types of climatic stressors which will pave its way to a future food crop.
View Article and Find Full Text PDFIntroduction Guillain-Barré syndrome (GBS) is an autoimmune disease affecting radicles and peripheral nerves resulting in acute flaccid paralysis. Respiratory failure, autonomic dysfunction, and secondary complications such as pneumonia, and venous thromboembolism are the major causes of death and disability in GBS. Cardiovascular complications play a major role in the prognosis of GBS patients.
View Article and Find Full Text PDFBackground: Economically developed countries continue to find that venous thromboembolism (VTE) is a major cause of morbidity and mortality.
Objective: To compare baseline risk profiles and patient workflow patterns between the United States (U.S.
J Dent Res Dent Clin Dent Prospects
December 2022
Background: In the recent day, there has been an exponential growth in the usage of clear aligners for orthodontic treatment. As with any removable appliance, the compliance of patients to remove it during ingestion of food is, at times, poor. Thus, the stability of the clear aligner to be "clear" becomes questionable.
View Article and Find Full Text PDFIn the era of antiretroviral therapy, the prevalence of Cryptococcal infection among HIV patients in developed countries has decreased considerably. However, ranks top among the critical priority pathogen that affects a wide range of immunocompromised individuals. The threat of is because of its incredibly multifaceted intracellular survival capabilities.
View Article and Find Full Text PDFBackground: Venous thromboembolism (VTE), encompassing both deep vein thrombosis (DVT) and pulmonary embolism (PE), is a leading cause of morbidity and mortality worldwide.
Methods: GARFIELD-VTE is a prospective, non-interventional observational study of real-world treatment practices. We aimed to capture the 36-month clinical outcomes of 10,679 patients with objectively confirmed VTE enrolled between May 2014 and January 2017 from 415 sites in 28 countries.
Approximately 50%-55% of high-grade serous ovarian carcinoma (HGSOC) patients have MYC oncogenic pathway activation. Because MYC is not directly targetable, we have analyzed molecular pathways enriched in MYC-high HGSOC tumors to identify potential therapeutic targets. Here, we report that MYC-high HGSOC tumors show enrichment in genes controlled by NRF2, an antioxidant signaling pathway, along with increased thioredoxin redox activity.
View Article and Find Full Text PDFLancet Infect Dis
September 2022
COVID-19-associated pulmonary mucormycosis (CAPM) remains an underdiagnosed entity. Using a modified Delphi method, we have formulated a consensus statement for the diagnosis and management of CAPM. We selected 26 experts from various disciplines who are involved in managing CAPM.
View Article and Find Full Text PDFIdentification of 2,6-diisopropylphenol by Raman spectroscopy using the TruScan Raman spectrum is validated by specificity test and robustness. HPLC assay method is developed to detect the 2,6-diisopropylphenol and its impurities A = determination of 2,6-diisopropylphenol; its main impurities related compound A = 2,6-diisopropylphenyl isopropyl ether, related compound B = 2,6-diisopropylquinone, and related compound C = 3,3'-5,5'-tetraisopropyl diphenol; and unknown impurities done by HPLC method. Related compound A and C determination has been developed by normal phase HPLC; good resolution peak shapes have resulted from the peak results.
View Article and Find Full Text PDFChemosphere
January 2022
In this study, Polyphenols functionalized Graphitic Hematite Nanocomposite (PGHN) was used as an adsorbent to remove Caesium (Cs) ions from a simulated solution. The nanocomposite was produced by synthesizing iron oxide nanoparticles using orange peel extract (OPE) as the reducing and capping agent in the presence of graphite produced from sugarcane bagasse. The nanocomposite exhibited a scaly morphology and the mean particle size of rhombohedral structured hematite nanoparticles was found to be 148.
View Article and Find Full Text PDFThis case report outlines the importance of an interdisciplinary approach and a patient centric outcome for the treatment of facial asymmetry resulting from hemifacial microsomia. Different treatment modalities are available to treat asymmetries. However, the best treatment outcome can be achieved only when the treatment plan is individualized for every patient.
View Article and Find Full Text PDFGarlic ( L.), is a predominant spice, which is used as an herbal medicine and flavoring agent, since ancient times. It has a rich source of various secondary metabolites such as flavonoids, terpenoids and alkaloids, which have various pharmacological properties.
View Article and Find Full Text PDFMyricetin is categorized under the secondary metabolite flavonoid which includes a diverse range of consumable plant parts, and it has a potential against several classes of cancer including cancers and tumors. In the present study, the anticancer potential of the unique flavonoid-myricetin in A549 lung cancer cells was evaluated. Among different doses of myricetin, 73 μg/ml was more effective to prevent the cancer cell growth.
View Article and Find Full Text PDFBackground And Objectives: Pleomorphic adenoma, being the most common benign tumors of salivary gland, is morphologically characterized by a biphasic pattern containing the epithelial and mesenchymal components. The modified myoepithelial cells present are thought to play an important role in its histologic diversity by the formation of extracellular matrix. The aim of the present study was to observe, compare and correlate the histomorphological diversity of epithelial and stromal components along with different morphological cell types of modified myoepithelial cells.
View Article and Find Full Text PDFLung ultrasound (LUS) has been proven to yield valuable information for lung and pleural pathology. It is well validated for assessing extravascular lung water. It can also be used to monitor stages of controlled lung de-aeration in whole lung lavage (WLL) which is the treatment for Pulmonary Alveolar Protienosis (PAP),characterized by abnormal surfactant in the alveoli affecting gas exchange .
View Article and Find Full Text PDFβ Tricalcium phosphate ceramic was used to reinforce nanofibers in composite mats produced via electrospinning of poly(vinyl alcohol) (PVA), polycaprolactone (PCL) and (PVA: PCL) bilayers. The role of TCP ceramic on morphology of nanocomposites, crystalline structure, functional groups and thermal behaviour of nanocomposites were characterized by SEM, EDAX, XRD, FTIR and DSC analysis. Ultrathin cross-sections of the obtained nanocomposites were morphologically investigated with SEM and all fabricated composites consisted of fibers with average fiber diameter (AFD) around 100 nm except PCL-TCP fibers having AFD in the range of 608 nm.
View Article and Find Full Text PDFBackground: Exposure to PM (fine particulate matter
Polyvinylalcohol (PVA) and Polyvinylpyrrolidone (PVP) blend incorporated with hydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP) is electrospun as nanofibrous composite scaffolds to act as suitable template for bone tissue engineering. Microscopic and spectroscopic characterizations confirm uniform integration of the crystalline calcium phosphate ceramics in the scaffolds. PVA-PVP blends are usually amorphous in nature and addition of phosphate ceramic particles specifically HAp elevates its crystalline behavior which is substantiated by XRD details.
View Article and Find Full Text PDFAustralas Phys Eng Sci Med
September 2016
Electroencephalographic (EEG) activity recorded during the entire sleep cycle reflects various complex processes associated with brain and exhibits a high degree of irregularity through various stages of sleep. The identification of transition from wakefulness to stage1 sleep is a challenging area of research for the biomedical community. In this paper, spectral entropy (SE) is used as a complexity measure to quantify irregularities in awake and stage1 sleep of 8-channel sleep EEG data from the polysomnographic recordings of ten healthy subjects.
View Article and Find Full Text PDFThe artificial cultivation of Ganoderma lucidum (MTCC1039) using Artocarpus heterophyllus as sawdust substrate was optimized and free radical scavenging activities of the generated fruiting bodies were investigated. The choice of A. heterophyllus as substrate was due to its easy availability in South India.
View Article and Find Full Text PDFJ Int Oral Health
September 2015
Aim: The aim of the present study was to evaluation and comparison of intermaxillary tooth size discrepancy among Class I, Class II division 1, and Class III subjects using Bolton's analysis.
Materials And Methods: The pre-treatment casts were selected from the records of patients attending the Department of Orthodontics of Meenakshi Ammal Dental College, Chennai. The sample consists of 180 pre-treatment casts with both sexes evenly distributed with 60 casts in each type of malocclusion, i.
Coactivator-associated arginine methyltransferase (CARM1/PRMT4)-mediated transcriptional coactivation and arginine methylation is known to regulate various tissue-specific differentiation events. Although CARM1 is expressed in the neural crest region in early development, coinciding with early neuronal progenitor specification, the role of CARM1 in any neuronal developmental pathways has been unexplored. Using a specific small-molecule inhibitor of CARM1-mediated H3R17 methylation in human embryonic stem cell line, we find that H3R17 methylation contributes to the maintenance of the astroglial cell population.
View Article and Find Full Text PDFJ Maxillofac Oral Surg
June 2013
This retrospective study was conducted to evaluate the role of platelet-rich plasma (PRP) in the reconstruction of segmental mandibular defects using iliac bone grafts. Thirteen patients underwent reconstruction of post-resection segmental defects of the mandible using titanium reconstruction plates, cortico cancellous iliac bone graft. The patients were randomly separated into two groups.
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