Publications by authors named "Uma Debi"

Background: The risk factors for interstitial lung disease (ILD) in rheumatoid arthritis (RA) are inconsistent among previous studies. Furthermore, the factors associated with the emergence of the recently defined progressive fibrosing (PF) phenotype are unknown. Herein, we analyze the risk factors for ILD in RA.

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  • Idiopathic pulmonary fibrosis is a serious lung disease characterized by lung scarring and the usual interstitial pneumonia pattern, leading to high mortality and frequent hospital visits.
  • This study reviewed CT scans from 65 patients with suspected usual interstitial pneumonia to assess complications like emphysema, pneumothorax, and infections.
  • The findings highlight the need for regular high-resolution CT scans to monitor patient conditions due to the severe complications associated with this disease.
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Background: Frequent chest CTs within a short period during follow-up of long COVID patients may increase the risk of radiation-related health effects in the exposed individuals. We aimed to assess the image quality and diagnostic accuracy of ultra-low-dose CT (ULDCT) chest compared to standard-dose CT (SDCT) in detecting lung abnormalities associated with long COVID.

Methods: In this prospective study, 100 long COVID patients with respiratory dysfunction underwent SDCT and ULDCT chest that were compared in terms of objective (signal-to-noise ratio, SNR) and subjective image quality (image graininess, sharpness, artifacts, and diagnostic accuracy along with the European guidelines on image quality criteria for CT chest), detection of imaging patterns of long COVID, CT severity score, and effective radiation dose.

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Many survivors of severe COVID-19 pneumonia experience lingering respiratory issues. There is limited research on follow-up chest imaging findings in patients with COVID-19 ARDS, particularly in relation to their mMRC dyspnea scores and pulmonary function tests (PFTs). This study addresses this gap by investigating the clinical characteristics, mMRC dyspnea scores, PFTs, and chest CT findings of COVID-19 ARDS patients at the 6 months post-recovery.

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  • - Chronic obstructive pulmonary disease (COPD) is a long-term lung condition that causes obstructed airways and lung damage, making it difficult for patients to breathe.
  • - The study evaluated oxygen-enhanced MRI (OE-MRI) and dynamic contrast-enhanced MRI (DCE-MRI) in 60 COPD patients to assess their ventilation and blood flow issues, finding that 87% of subjects exhibited these abnormalities.
  • - Results showed a strong correlation between the severity of ventilation-perfusion defects observed in MRI and the clinical severity of COPD, particularly between different stages of disease according to the GOLD classification.
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  • Current guidelines recommend using 20-40 mg/day of oral prednisolone for pulmonary sarcoidosis treatment, but the effectiveness of the higher dose (40 mg/day) compared to the lower dose is uncertain.
  • A clinical trial was conducted with 86 participants randomly assigned to receive either high-dose or low-dose prednisolone for 18 months, with outcomes measuring relapse rates, lung function, side effects, and quality of life.
  • The study found no significant differences in relapse rates, lung function changes, or quality of life improvements between the two doses, indicating that high-dose prednisolone does not offer superior benefits over the lower dose.
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Gastrointestinal tuberculosis (GITB) and Crohn's disease (CD) are close mimics. This prospective study aimed to evaluate the diagnostic performance of perfusion computed tomography (CT) in differentiating GITB from CD. Consecutive patients with ileocaecal thickening underwent perfusion CT of the ileocaecal region between January 2019 and July 2020.

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The rapid increase in the number of CT acquisitions during the COVID-19 pandemic raised concerns about increased radiation exposure to patients and the resultant radiation-induced health risks. It prompted researchers to explore newer CT techniques like ultra-low dose CT (ULDCT), which could improve patient safety. Our aim was to study the utility of ultra-low dose CT (ULDCT) chest in the evaluation of acute COVID-19 pneumonia with standard-dose CT (SDCT) chest as a reference standard.

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Background: Cardiac involvement in Takayasu arteritis (TA) is the major cause of morbidity and mortality. Cardiovascular magnetic resonance (CMR) is an excellent modality for the assessment of myocardial involvement. Studies have shown myocardial involvement in 25%-27% of patients.

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Chronic pulmonary aspergillosis (CPA) is a life-threatening respiratory fungal infection that is almost exclusively seen in patients with preexisting structural lung disease with no or mild immunosuppression. The clinical presentation and imaging findings are varied and often pose a diagnostic challenge; and the disease is often present for a long time before being correctly diagnosed. High-resolution chest computed tomography is the imaging modality of choice because it helps identify various forms of CPA, which can range from a simple aspergilloma and chronic cavitary form, to the subacute invasive and end-stage fibrotic form.

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To evaluate the role of magnetic resonance imaging (MRI) chest as an alternative modality to CT chest for follow-up of patients recovered from severe COVID-19 acute respiratory distress syndrome (ARDS). A total of 25 subjects (16 [64%] men; mean age 54.84 years ± 12.

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Background: Carotid artery stenosis (CAS) is an established risk factor for peri-operative neurological complications in patients following coronary artery bypass grafting (CABG). However, routine pre-surgical screening for CAS is still a matter of debate. This study was conducted to study the prevalence of asymptomatic carotid artery disease in patients undergoing CABG and to determine the predictors of significant carotid stenosis in them.

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  • Cardiomyopathy is a major health issue for boys with Duchenne muscular dystrophy (DMD), making early diagnosis essential for effective treatment.
  • This study compared cardiac MRI (CMRI) and echocardiography techniques (TTE, TDI, STE) to assess cardiomyopathy in ambulatory boys aged 7 to 15 with DMD.
  • Results showed that while echocardiography indicated fewer issues, CMRI revealed a much larger number of boys with early signs of cardiomyopathy, highlighting the importance of CMRI for early detection.
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Cardiac lymphoma is a rare entity. In this setting, the secondary involvement of the heart is far more frequent than the primary cardiac lymphoma. Herein, we present an autopsy case of a disseminated anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma with a dominant mediastinal involvement.

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Computed tomography (CT) of the chest plays an important role in the diagnosis and management of coronavirus disease 2019 (COVID-19), but it should not be used indiscriminately. This review provides indications of CT chest in COVID-19 suspect, positive and recovered patients based on the current scientific evidence and our personal experience. CT chest is not indicated as a routine screening modality due to its poor sensitivity and specificity.

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A significant number of patients after initial recovery from COVID-19 continue to experience lingering symptoms of the disease that may last for weeks or even months. Lungs being the most commonly affected organ by COVID-19, bear the major brunt of the disease and thus it is imperative to be aware of the evolution of the pulmonary parenchymal changes over time. CT chest is the imaging modality of choice to evaluate post-COVID lungs.

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Background: Transcatheter device closure is a safe procedure recommended in children with patent ductus arteriosus (PDA). While the standard procedure uses arterial and venous femoral access, it poses risk of vascular complications especially in young infants. Isolated venous approach has been tried in a few studies and was found to be non-inferior to the standard technique.

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Isolated right-sided valvular disease is a much less recognised entity when compared with left-sided valvular heart disease. Almost all the cases of combined pulmonary valve with tricuspid valve involvement are a consequence of underlying carcinoid heart disease. Moreover, severe calcification of tricuspid valve is an extremely unusual finding.

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Hydatid disease is a parasitic infestation caused by the larval stage of . It can infest any part of the body; however, aortic hydatid disease is rare. Involvement of the abdominal aorta is usually due to embolization from cardiac hydatid cysts or direct invasion and can be present at intravascular or intramural locations.

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Objective: This study describes the computed tomography (CT) features in patients with cardiac or circulatory arrest.

Methods: We retrospectively reviewed the CT of 5 patients (age range - 6-50 years) who had circulatory arrest while undergoing imaging, within a 12 month period in our Trauma and Emergency Centre. The presence or absence of contrast in the right and left chambers of heart, venous and arterial system, contrast density, and layering were assessed.

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Contrast blood level in intrahepatic inferior vena cava (IVC) on arterial contrast-enhanced CT images is referred to as IVC layering or IVC contrast level sign. This sign is important to recognize as it has dismal prognosis and requires immediate attention. The causes described in literature include cardiogenic shock, cardiac arrest and cardiac tamponade.

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