Genome-wide temporal landscaping of DNA methylation in pregnant women delivering at term: a GARBH-InI study.

We performed an epigenome-wide longitudinal DNA methylation study on an Indian cohort of pregnant women, GARBH-Ini, at three time points during pregnancy and at delivery. Our aim was to identify temporal DNA methylation changes in maternal peripheral blood during the period of gestation and assess their impact on biological pathways critical for term delivery. Significantly differentially methylated CpGs were identified by linear mixed model analysis (Bonferroni p < 0.