Morphology and Phylogenetic Analysis of Henneguya sp. Infecting the Orange-Spotted Snakehead (Channa Aurantimaculata) from Tamil Nadu, India.

Purpose: Henneguya sp. is a crucial myxosporean parasite known to cause milky flesh or tapioca disease in the freshwater fish population, leading to heavy mortality. Studies to investigate its host range and to monitor their prevalence in wild and aquacultured fish are necessary.

Comparison of Thyroid Function Tests Among Type 2 Diabetes Patients With and Without Diabetic Nephropathy and Controls.

Background:  Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder associated with hyperglycemia and impaired insulin function. Diabetic nephropathy (DN) is a common complication of T2DM, characterized by progressive kidney damage. Thyroid dysfunction, particularly hypothyroidism, has been increasingly recognised as a significant factor influencing the progression of DN.

Molecular characterization of lymphocystis disease virus in Indian glass fish: first report from the Andaman Islands.

Here, we report the first detection of lymphocystis disease virus (LCDV) in Indian glass fish in the Andaman Islands, India. Microscopic examination revealed the presence of whitish clusters of nodules on the fish's skin, fins, and eyes. The histopathology of the nodules revealed typical hypertrophied fibroblasts.

Effect of paddy sourcing methods on the volume of rice milled by rice millers in Mwea, Kirinyaga county, Kenya.

Rice millers access paddy through private traders, cooperatives, individual farmers, and village agents. These methods determine the capacity utilization of the mills, costs incurred, and profitability of the rice milling business. This article aimed at determining the effect of paddy sourcing methods on the volume of rice milled by small and medium-scale rice millers in Kenya.

Unraveling the host-parasite interaction: immune response in Oreochromis mossambicus to Cymothoa eremita (Isopoda, Cymothoidae) infection.

The host immune response in Oreochromis mossambicus during natural infection with the isopod Cymothoa eremita was investigated. The naturally infected fishes were examined for enzyme profile, viz., respiratory burst activity (RBA), myeloperoxidase activity (MPO), and expression of immune-related genes, viz.

Toxicological effect of endocrine disrupting insecticide (deltamethrin) on enzymatical, haematological and histopathological changes in the freshwater iridescent shark, Pangasius hypothalamus.

This study investigated the deltamethrin (DMN) induced harmful effects on Pangasius hypophthalmus using enzymatic activity, haematological, and histopathological changes. LC value was 0.021 mg/L at 96 h, and sublethal toxicity was tested for 45 days at two `concentrations (i.

Synthesis of 1,2,3-triazole-1,3,4-thiadiazole hybrids as novel α-glucosidase inhibitors by in situ azidation/click assembly.

α-Glucosidase inhibition is widely used in the oral management of diabetes mellitus (DM), a disease characterized by high blood sugar levels (hyperglycemia) and abnormal carbohydrate metabolism. In this respect, a series of 1,2,3-triazole-1,3,4-thiadiazole hybrids 7a-j were synthesized, inspired by a copper-catalyzed one-pot azidation/click assembly approach. All the synthesized hybrids were screened for inhibition of the α-glucosidase enzyme, displaying IC values ranging from 63.

Inhibition of α-glucosidase enzyme by 'click'-inspired pharmacophore framework 1,3,4-thiadiazole-1,2,3-triazole hybrids.

α-Glucosidase inhibitors are important oral antidiabetic drugs that are used alone or in combination therapy. In this regard, 1,3,4-thiadiazoles-1,2,3-triazoles were designed, synthesized and evaluated for α-glucosidase enzyme inhibition. The applied synthesis protocol involved a 'click' reaction between a novel alkyne derived from a 1,3,4-thiadiazole derivative and phenylacetamide azides.

Flavone-1,2,3-triazole derivatives as potential α-glucosidase inhibitors: Synthesis, enzyme inhibition, kinetic analysis and molecular docking study.

α-Glucosidase inhibitors are considered prime therapeutics in the management of type-2 diabetes and are preferred due to their localized action ushered by limited side effects. In this regard, nineteen new flavone-1,2,3-triazole derivatives have been designed and synthesized via utilizing an efficient click reaction protocol, and screened for the inhibition of the α-glucosidase enzyme. The reaction conditions were mild, good yielding and required easy work up.

Scaling and Disagreements: Bias, Noise, and Ambiguity.

Crowdsourced data are often rife with disagreement, either because of genuine item ambiguity, overlapping labels, subjectivity, or annotator error. Hence, a variety of methods have been developed for learning from data containing disagreement. One of the observations emerging from this work is that different methods appear to work best depending on characteristics of the dataset such as the level of noise.

Early responses in Penaeus vannamei during experimental infection with Enterocytozoon hepatopenaei (EHP) spores by injection and oral routes.

Hepatopancreatic microsporidiosis caused by Enterocytozoon hepatopenaei (EHP) is associated with severe production losses in Penaeus vannamei farming. Early responses in P. vannamei experimentally infected with EHP was assessed in this study by feeding infected hepatopancreatic tissue and by injecting purified EHP spores (∼1 × 10 Spores/shrimp).

The Genotoxic and Cytotoxic Effects of CT Scan on Buccal Epithelial Cells.

Background: Diagnostic radiation is reported to cause significant damage in buccal cells, while the same effects after natural cell turn over cycle were not checked for in previous studies. The buccal cells were studied in patients exposed to computed tomography (CT) scans for evaluating the cells with micronuclei and cytotoxic changes, namely, pyknotic cells, karyorrhectic cells and karyolytic cells. The pre-exposure counts were compared with postexposure counts on 10 and 20 days corresponding to first and second cell turnover cycles.

Outbreak of hirudiniasis in aquarium-reared albino red-bellied pacu Piaractus brachypomus.

We report hirudiniasis caused by the leech Hemiclepsis marginata asiatica Moore, 1924 in albino red-bellied pacu (pirapitinga) Piaractus brachypomus (Cuvier, 1818), constituting the first documentation of a freshwater fish species being affected in India. The outbreak occurred in a tank of an aquarium-fish retailer; infested fish appeared asphyxiated, unable to swim or swimming upside down, with cloudy eyes and body with thick mucus secretion. The prevalence and mortality was 100%, with a mean intensity of 81 leeches per fish.

Area efficient folded undecimator based ECG detector.

This paper presents an area-efficient folded wavelet filter-based Electrocardiogram (ECG) detector for cardiac pacemakers. The modified folded undecimator based detector consists of Wavelet Filter Bank, QRS complex detector with Generalized Likelihood Ratio Test (GLRT) block and noise detector. A high-level transformation technique such as folding transformation and Cutset retiming are applied to the GLRT block in order to reduce the silicon area.

Evaluation of ethanol fermentation efficiency of sweet sorghum syrups produced by integrated dual-membrane system.

1G ethanol from sweet sorghum can be a better alternative to various other sources used for its production. The commercial feasibility is dictated by the high sugar containing varieties, their transport to ethanol plants, storage and availability of robust yeast strains for the fermentation. Eight sweet sorghum cultivars namely CSV19SS, CSV24SS, CSV27, CSV32F, PV, SSV84, RVICSH, SPV1871, SSV74 were tested for their sugar content and varieties-SSV84 and CSV24SS were containing sugar content of 170-190 g/L.

Channa brunnea, a new species of snakehead (Teleostei: Channidae) from West Bengal, India.

Channa brunnea, a new species of snakehead fish lacking pelvic fins, from West Bengal, India, is distinguished from its pelvic fin-less congeners by possessing an uniform dark brown body, ochre to bright-orange blotches on the caudal fin, fewer dorsal and anal-fin rays (35-37 vs. 47-51 and 24 vs. 28-32, respectively), fewer vertebrae (43 vs.

Virtual screening of novel compounds as potential ER-alpha inhibitors.

Majority of breast cancers diagnosed today are estrogen receptor (ER)-positive, however, progesterone receptor-positive (PR-positive) is also responsible for breast cancer. Tumors that are ER/PR-positive are much more likely to respond to hormone therapy than tumors that are ER/PR-negative. Nearly 105 ERa inhibitors from literature when docked resulted in 31 compounds (pyrazolo[1,5-a]pyrimidine analogs and chromen-2-one derivatives) with better binding affinities.

A Review of Pancreatic Cancer: Epidemiology, Genetics, Screening, and Management.

Pancreatic cancer ranks among the causes of cancer-related deaths. The average size of pancreatic cancer during diagnosis is about 31 mm and has not changed significantly over the past 30 years. Poor early diagnosis of a tumour has been attributed to the late-presenting symptoms.

Non-invasive imaging of fluorescence-labeled bacterial distributions in aquatic species.

imaging is becoming an advanced tool for noninvasive distribution of longitudinal small animals. However, the aquatic species have been limited to the optical imaging of noninvasively tracking on pathogen distribution. The purpose of this study was to develop shell-less fish and shrimp models of non-invasive imaging technique for visualization of pathogens.

Design, synthesis and in vitro study of densely functionalized oxindoles as potent α-glucosidase inhibitors.

Diabetes a non-communicable disease occurs either due to the lack of insulin or the inability of the human body to recognize it. The recent data indicated an increase in the trend of people diagnosed with type 2 diabetes mainly due to unhealthy life style. Here in we report a new class of oxindole derivatives 6a-kvia scaffold hopping of known α-glucosidase inhibitors 1-4.

Biochemical changes and tissue distribution of Enterocytozoon hepatopenaei (EHP) in naturally and experimentally EHP-infected whiteleg shrimp, Litopenaeus vannamei (Boone, 1931), in India.

Stunted growth in pond-reared Litopenaeus vannamei was observed in different farms located in Tamil Nadu and Andhra Pradesh, India. No mortality was associated with stunted growth. PCR assay on these samples revealed the presence of Enterocytozoon hepatopenaei (EHP) in stunted shrimp.

Association of estrogen receptor 1 (ESR1) haplotypes with risk for systemic lupus erythematosus among South Indians.

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder involving genetic, epigenetic and environmental factors and has higher incidence in women. In this study, we explored the association of estrogen receptor 1 (ESR1) rs2234693 (PvuII) and rs9340799 (XbaI) polymorphisms with susceptibility to SLE. PCR-RFLP and ELISA were used for genetic analysis and determination of specific autoantibodies, respectively.