Publications by authors named "Ulysses Wu"

Article Synopsis
  • Breakthrough SARS-CoV-2 infections post-vaccination are a major concern, particularly for cancer patients who are at higher risk of severe outcomes.
  • A study analyzed 2,486 cancer patients with confirmed infections, focusing on the impact of receiving 2 or 3 doses of mRNA vaccines, looking at mortality and hospitalization rates.
  • Results showed that vaccinated individuals had significantly lower 30-day mortality and hospitalization rates compared to unvaccinated patients, with those receiving 3 doses having the best outcomes.
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We present a rare case of a 71-year-old female. She has a history of irritable bowel syndrome that is diet controlled. However she presented to the emergency department (ED) with a history of diarrhea, weakness, chills and right lower back pain for two days.

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Article Synopsis
  • The study investigates the frequency and outcomes of coinfections in cancer patients who also have COVID-19, a group at high risk for such infections.
  • Among 8,765 patients analyzed, 16.6% developed coinfections, predominantly bacterial, with specific risk factors identified such as age, sex, and existing health conditions.
  • Co-occurrence of bacterial and fungal infections significantly increased the 30-day mortality rates, highlighting the severe impact of these coinfections in this vulnerable population.
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Greater efforts aimed at using antimicrobials sparingly and appropriately, as well as developing new antimicrobials with activity against multidrug-resistant pathogens, are ultimately needed to address the threat of antimicrobial resistance. This article describes the evidence-based management of inpatient infections caused by resistant bacteria and the role family physicians can play in reducing further development of resistance through antimicrobial stewardship practices.

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Clinician education and prospective audit and feedback interventions, deployed separately and concurrently, did not reduce antimicrobial use errors or rates compared to a control group of general medicine inpatients at our public hospital. Additional research is needed to define the optimal scope and intensity of hospital antimicrobial stewardship interventions. Infect Control Hosp Epidemiol 2017;38:857-859.

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Brucellosis is the most common worldwide zoonosis which continues to remain a significant worldwide health problem and burden. Transmission usually occurs secondary to direct or indirect exposure to certain animals, but a major mode of transmission is the ingestion ofunpasteurized milk or milk products from infected animals. 'Ihe disease has a geographic distribution including the Mediterranean basin and Arabian Peninsula, India, Mexico, and parts of Central and South America.

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A 44-year-old man from Connecticut with no significant past medical history presented to the ED with a 2-week history of sore throat and fatigue, subsequently developing cough, dyspnea, fevers, and chills. The patient reported buying an old camper van and noticed a large infestation of rodent droppings, which he had cleaned thoroughly from the cabin. He used the camper van on several camping trips in Vermont, and symptoms started on his return.

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We present the case ofa26-year-old female who presented to the hospital with pneumococcal meningitis. A review of her records showed atrophic spleen, and a hypercoagulable workup was positive for Systemic Lupus Erythematous (SLE)/Antiphospholipid Antibody Syndrome (APS). An autosplenectomy from thrombotic occlusion of the splenic artery made her susceptible to pneumococcal meningitis.

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Objective: To describe and measure reliability of a computer-assisted method of case vignette assembly and expert review to assess the appropriateness of antimicrobial therapy for hospitalized adults.

Design: Feasibility and reliability analysis of computer-assisted tool used to compare the effects of antimicrobial stewardship interventions.

Setting: Public teaching hospital.

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