Novel Anthraquinone Derivatives and Their Complexes with Metal Ions with Anticancer Activity: Structure/Redox and Chelation Activity Correlations.

Some specific anthraquinone derivatives (AQs) are known to be used widely as effective chemotherapeutic agents in the treatment of cancer. However, their fundamental shortcoming is the high rate of cardiotoxicity observed in treated patients, which is thought to be caused by the increase in production of reactive oxygen species (ROS) catalyzed by iron and copper. The development of improved AQs and other anticancer drugs with enhanced efficacy but reduced toxicity remains a high priority.

NMR Study of Water-Soluble Carotenoid Crocin: Formation of Mixed Micelles, Interaction with Lipid Membrane and Antioxidant Activity.

Crocin is a unique water-soluble carotenoid found in crocus and gardenia flowers. Crocin has been shown to have a variety of pharmacological activities, such as antioxidant, anti-cancer, memory improvement, antidepressant, anti-ischemia, blood pressure lowering and aphrodisiac, gene protection and detoxification activities. Due to their amphiphilicity, crocin molecules form concentration-dependent self-associates (micelles) in a water solution.

Changes in coastal ecosystems affected by overburden dumping from amber open-cut mining on the Sambia Peninsula (Baltic Sea).

The Sambia Peninsula (Kaliningrad region) is historically well known for its amber mining. The 2019 year was the last year of direct overburden disposal into the Baltic Sea as a part of technological amber mining process. The extremely high-suspended particulate matter concentrations during that disposal were recorded immediately after the discharge of significant volumes of pulp and reached 200 mg/L.

The Baltic Sea methane pockmark microbiome: The new insights into the patterns of relative abundance and ANME niche separation.

Pockmarks are important "pumps", which are believed to play a significant role in the global methane cycling and harboring a unique assemblage of very diverse prokaryotes. This study reports the results of massive sequencing of the 16S rRNA gene V4 hypervariable regions for the samples from thirteen pockmark horizons (the Baltic Sea) collected at depths from 0 to 280 cm below seafloor (cmbsf) and the rates of microbially mediated anaerobic oxidation of methane (AOM) and sulfate reduction (SR). Altogether, 76 bacterial and 12 archaeal phyla were identified, 23 of which were candidate divisions.

[Carfilzomib, lenalidomide and dexamethasone in relapsed/refractory multiple myeloma patients: the real-life experience].

Background: Carfilzomib, lenalidomide, and dexamethasone (KRd) have been approved for the treatment of relapsed and refractory multiple myeloma (RRMM) based on ASPIRE clinical trial.

Aim: Analysis of efficacy and safety of KRd in routine clinical practice.

Materials And Methods: The prospective analysis included patients with MM who received at least one line of previous therapy.

Influence of land-based Kaliningrad (Primorsky) amber mining on coastal zone.

In this paper, we report on the pollution in the coastal zone of the South-Eastern Baltic Sea (Russian coast). It was studied through a range of methods, including analyses potential water quality indicators (WQIs) and potentially harmful elements (PHEs). A contamination factor and modified degree of contamination were used for describing the contamination of the sediments by toxic substances.

[Gene pool of Siberian Tatars: Five ways of origin for five subethnic groups].

Siberian Tatars form the largest Turkic-speaking ethnic group in Western Siberia. The group has a complex hierarchical system of ethnographically diverse populations. Five subethnic groups of Tobol-Irtysh Siberian Tatars (N = 388 samples) have been analyzed for 50 informative Y-chromosomal SNPs.

[CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ANEMIA: CLINICAL MANIFESTATIONS AND THERAPEUTIC STRATEGY].

Unlabelled: Anemia refers to manifestations of systemic inflammation in chronic obstructive pulmonary disease (COPD) and a factor aggravating the disease.

Objective: To study gender characteristics of anemia in patients with COPD, to increase the effectiveness of treatment through the use of pharmacological agents erythropoietin and enteral iron.

Materials And Methods: The paper presents clinical data on 74 patients with stage II/III COPD and anemia along with results of the treatment of 49 patients who received standard therapy in addition to epoetin and Sorbiferdurules.