Publications by authors named "Ulugbek Mirzaev"
Article Synopsis
- The study investigates hepatitis C (HCV) transmission dynamics among specific populations in Japan, particularly people who inject drugs (PWID) and men who have sex with men (MSM), to understand impediments to HCV elimination despite low overall infection rates.
- Researchers analyzed data from HCV-infected individuals at Osaka National Hospital, conducting genetic sequencing to determine genotype distribution and check for recombination among samples collected between 2010 and 2023.
- The results indicate that MSM status affects HCV transmission routes among PWID, with distinct strains observed in different groups, emphasizing the need for targeted control measures for both PWID and MSM to enhance HCV elimination efforts in Japan.*
Article Synopsis
- Hepatitis E virus (HEV) causes around 20 million infections each year, and while PCR is the best diagnostic method, it's costly and complex compared to antibody tests that are more affordable but vary in accuracy based on several factors.
- A thorough review of literature compared immunoglobulin M (IgM) and immunoglobulin G (IgG) antibody tests to PCR, analyzing data from 8054 blood samples across 21 studies.
- The study found IgM antibody tests to have 83% sensitivity and 98% specificity, while IgG tests had 74% sensitivity and 89% specificity, indicating that antibody assays can effectively detect HEV when PCR isn't an option, making them useful diagnostic alternatives.
Objective This study assessed the accuracy of detecting Human Papillomavirus (HPV) DNA in urine samples compared to cervical samples and identified factors associated with HPV DNA positivity in Uzbekistan. Methods A total of 218 paired urine and cervical samples were collected from women in Uzbekistan. HPV DNA was detected using polymerase chain reaction (PCR) with genotyping.
View Article and Find Full Text PDFObjective This study aims to analyze the relationship between access to safe drinking water and the incidence of hepatitis A in Uzbekistan from 2010 to 2023 to inform public health strategies for disease prevention. Methods We utilized hepatitis A incidence data from the Sanitary and Epidemiological Well-Being and Public Health Authority and drinking water provision data from the Government Statistics Agency of Uzbekistan. A linear regression analysis was performed using R 4.
View Article and Find Full Text PDFBackground: Comprehensive details on Hepatitis C virus (HCV) infection in Myanmar are lacking. This study determined the prevalence of HCV antibodies and ribonucleic acid (RNA) and the distribution of HCV genotypes across different populations in Myanmar from 1990 to 2023.
Material And Methods: A systematic search in PubMed, Web of Science, Scopus, and local journals identified studies reporting on HCV antibodies, RNA, and genotypes, excluding clinical research related to liver disease prognosis.
Article Synopsis
- Hepatitis Delta Virus (HDV) is a virus that can make liver damage worse for people who already have Hepatitis B.
- The study looked at how good different tests are at finding HDV in patients and included several research studies.
- It found that tests for Anti-HDV IgG are really good at detecting HDV, while tests for Total Anti-HDV and Anti-HDV IgM are not as accurate.
Article Synopsis
- A study was conducted to create conversion equations between five different quantitative tests for SARS-CoV-2 anti-S antibodies and to evaluate the agreement of three qualitative tests for anti-N antibodies among vaccinated healthcare workers in Japan.
- Strong correlations were found between the quantitative tests for anti-S antibodies, allowing for the development of conversion formulas to compare results across different tests.
- The agreement among the qualitative anti-N antibody tests was substantial overall but decreased over time, indicating potential challenges in comparing COVID-19 exposure studies based on these measurements.
Introduction: The severity and clinical outcome of COVID-19 depend on virus-specific factors and the host's inflammatory response. Identifying biomarkers of severe COVID-19 is a crucial condition and predicts disease severity.
Methodology: This study enrolled a total of 167 patients with COVID-19.
Article Synopsis
- The study assessed hepatitis E seroprevalence across Southeast Asia by analyzing 66 papers and data from 44,850 individuals, finding a pooled IgG prevalence of 21.03% and a higher prevalence in high-risk groups compared to the general population.
- The highest IgG prevalence was in Myanmar (33.46%), while Malaysia had the lowest (5.93%), with IgM prevalence peaking in Indonesia (12.43%) and also lowest in Malaysia (0.91%).
- A temporal analysis from 1987 to 2023 indicated an increasing trend in both IgG and IgM prevalence, highlighting the growing burden of hepatitis E and the need for public health interventions.
Article Synopsis
- The study developed a cost-effective in-house ELISA for detecting hepatitis E virus (HEV) in pregnant women in Siem Reap, Cambodia.
- Out of 1565 tested women, 11.6% were found to be anti-HEV positive, with higher prevalence in older age groups, specifically those over 35 years.
- The in-house ELISA showed comparable sensitivity and specificity to commercial tests, making it a promising tool for HEV screening in resource-limited settings, especially for public health initiatives.
Background: Symptoms after novel coronavirus disease 2019 (COVID-19) recovery by severe acute respiratory syndrome coronavirus 2 strains are unspecified.
Methods: This self-administered questionnaire-based study was conducted to investigate symptoms after COVID-19 recovery at one of the main hospitals for COVID-19 treatment in Hiroshima, Japan, from September 2020 to March 2022 for patients who visited follow-up consultations after COVID-19. Study subjects were divided into four groups (Wild-type, Alpha, Delta, and Omicron periods) according to COVID-19 onset date.
This study aimed to investigate the prevalence trend of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and their genotype distribution among hemodialysis patients, determining their long-term prognosis and the risk factors to the mortality. This cohort study used both the medical data and the blood samples of hemodialysis patients at nine dialysis centers in Hiroshima from 1999 to 2017. Hepatitis B surface antigen (HBsAg) and anti-HCV were screened and then amplification was done to positive sera by polymerase chain reaction for genotyping.
View Article and Find Full Text PDF