Synopsis of recent research by authors named "Ulrike Pag"
- Ulrike Pag's research primarily focuses on the mechanisms and properties of antimicrobial peptides, specifically defensins, and their interactions with microbial membranes and cell wall precursors, including novel synthetic variants and natural peptides.
- Key findings highlight the unique modes of action of various defensins, such as plectasin binding to the bacterial cell wall precursor Lipid II and human beta-defensin 3's ability to inhibit biosynthetic pathways in Staphylococcus aureus, revealing distinct pathways for bacterial eradication.
- Pag's work also explores the optimization of peptide structures through rational design and chemical synthesis, aiming to enhance antimicrobial efficacy and selectivity against both microbial and host cells, which could pave the way for new antibiotic development strategies.
