Alcohol-mediated renal denervation in patients with hypertension in the absence of antihypertensive medications.

Background: Ultrasound and radiofrequency renal denervation (RDN) have been shown to safely lower blood pressure (BP) in hypertension.

Aims: The TARGET BP OFF-MED trial investigated the efficacy and safety of alcohol-mediated renal denervation (RDN) in the absence of antihypertensive medications.

Methods: This randomised, blinded, sham-controlled trial was conducted in 25 centres in Europe and the USA.

Impact of angiotensin receptor blocker product recalls on antihypertensive prescribing in Germany.

In Germany, ~8 million patients take angiotensin receptor blockers (ARBs) and 2.25 million of them valsartan. In 2018, contamination of generic ARBs with probable carcinogenic nitrosamines resulted in more than 30 recalls.

Effects of six-week sprint interval or endurance training on calculated power in maximal lactate steady state.

The purpose of the study was to evaluate and compare the influence of sprint interval training (SIT) and endurance training (ET) on calculated power in maximal lactate steady state (PMLSS) (influenced by the maximal lactate production rate (⩒La) and maximal oxygen uptake (⩒O)). Thirty participants were randomly assigned to the a) SIT, b) ET, or c) control group (n = 10 each). Each session consisted of four to six repetitions of 30 s all-out effort Wingate anaerobic tests (SIT) or 60 min cycling at 1.