IDH1/2 mutations in WHO grade II astrocytomas associated with localization and seizure as the initial symptom.

Introduction: Seizures are the most common initial symptom in patients with low-grade glioma and their occurrence strongly depends on the tumor location. The majority of low-grade gliomas reveal mutations in the genes encoding isocitrate-dehydrogenase 1 (IDH1) or 2 (IDH2). These mutations are associated with metabolic changes that are potentially epileptogenic.

Emotional content does not interfere with verbal memory in patients with temporal lobe epilepsy.

In healthy humans, memory for words with emotional valence is better than memory for neutral words. At the same time, the word preceding the emotional word in a word list learning task is remembered less often than other neutral words. Both effects, enhanced memory for emotional words and retrograde amnesia for preceding words, are dependent on intactness of the amygdala.

fMRI correlates of interictal epileptic activity in patients with idiopathic benign focal epilepsy of childhood. A simultaneous EEG-functional MRI study.

EEG-correlated fMRI (EEG/fMRI) can identify alterations of brain function associated with interictal epileptiform discharges (IED). fMRI activation can localize the irritative zone and indicate functional disturbance distant from the spike focus. This might be of particular interest in paediatric epilepsy syndromes with frequent IED.

Linking generalized spike-and-wave discharges and resting state brain activity by using EEG/fMRI in a patient with absence seizures.

Purpose: To illustrate a functional interpretation of blood oxygen level-dependent (BOLD) signal changes associated with generalized spike-and-wave discharges in patients with absence seizures and to demonstrate the reproducibility of these findings in one case.

Methods: In a 47 year-old patient with frequent absence seizures, BOLD signal changes during generalized spike-and-wave discharges (GSWD) were mapped by using simultaneous and continuous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) at 1.5 T and 6 months later at 3 T.

Spontaneous dissociation during functional MRI experiments.

It is assumed that the procedures of functional magnetic resonance imaging (fMRI) are able to provoke significant dissociative responses. Trait and state dissociation of 32 healthy subjects undergoing fMRI have been recorded. At least one-third of the subjects showed dissociative responses of very large effect size (d=4.

Aggressive behavior of epilepsy patients in the course of levetiracetam add-on therapy: report of 33 mild to severe cases.

Levetiracetam (LEV) was shown to be very efficacious and well tolerated as add-on therapy for refractory epilepsy. Here we report 33 patients with longstanding histories of epilepsy who experienced aggressive episodes during LEV therapy. This corresponds to 3.