Publications by authors named "Ulrike Huegel"

Article Synopsis
  • - CKD often causes problems like high levels of phosphate and parathyroid hormone (PTH), leading to bone issues and increased heart disease risk; researchers studied the role of osteoblast-specific Gα signaling in this condition.
  • - They created mice with a knockout (KO) of the Gα pathway and found that these mice had altered bone structure, with increased blood calcium levels but reduced bone density, particularly when on a high phosphate diet.
  • - The study showed that disruption of the Gα signaling in osteoblasts affects calcium balance and worsens bone disease in CKD, highlighting its importance in bone health during high phosphate exposure.
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Klippel-Trénaunay syndrome is characterized by a persistent lateral embryonic vein. This so-called marginal vein has a large diameter causing venous stasis and venous hypertension because of the absence of valves along its entire length. The extensive diameter of the vein impedes successful treatment by sclerotherapy.

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Catheter-directed thrombolysis for iliofemoral deep venous thrombosis (DVT) aims to reduce acute leg symptoms and to prevent the post-thrombotic syndrome. There are no data from controlled trials in pregnant patients. Reports of thrombolysis for treatment of DVT during pregnancy are scarce.

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Since IGF-I is an important chondrocyte growth factor, we sought to examine the intracellular mechanisms by which it exerts two of its pivotal effects, stimulation of proliferation and differentiation. We used the mesenchymal chondrogenic cell line RCJ3.1C5.

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