Publications by authors named "Ulrike Goller"
Article Synopsis
- Accurate 24-hour urine collections are essential for estimating individual salt intake, but a single collection may not suffice to detect small differences in intake levels.
- A study involving 10 men simulating a Mars flight controlled dietary salt intake and measured urinary salt recovery, finding a high recovery rate that indicates a stable sodium balance.
- Increasing the number of 24-hour urine samples from one to seven significantly improves the accuracy of detecting changes in salt intake, which is important for both patient management and research trials.
The steady-state concept of Na(+) homeostasis, based on short-term investigations of responses to high salt intake, maintains that dietary Na(+) is rapidly eliminated into urine, thereby achieving constant total-body Na(+) and water content. We introduced the reverse experimental approach by fixing salt intake of men participating in space flight simulations at 12 g, 9 g, and 6 g/day for months and tested for the predicted constancy in urinary excretion and total-body Na(+) content. At constant salt intake, daily Na(+) excretion exhibited aldosterone-dependent, weekly (circaseptan) rhythms, resulting in periodic Na(+) storage.
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