Publications by authors named "Ulrika Klopcic"
Article Synopsis
- The Ki-67 proliferative index (PI) is crucial for diagnosing nodal B-cell lymphoma (nBCL), but its evaluation in cytological samples lacks standardization.
- This study aimed to create a consistent method for accurately measuring Ki-67 PI in cytological slides to distinguish between less aggressive (indolent) and more aggressive forms of nBCL.
- The findings indicated a strong correlation between manual and flow-cytometry counting of lymphoma B cells and established specific cut-off values for Ki-67 PI using various counting methods, effectively differentiating between indolent and aggressive nBCLs.
Background: p16/Ki-67 dual immunocytochemical staining (DS) has been proven as a sensitive and specific test for triage of HPV positive women with good reproducibility and accuracy. However, implementation of the test into an organized screening program (OSP) is not easy. The aims of this study were to compare the performance and agreement of DS results among three Slovenian cytopathological laboratories involved in the national OSP, and to define cases where staining results can be difficult to interpret.
View Article and Find Full Text PDFBackground To overcome obstacles within the Slovenian organised cervical cancer screening programme, a randomised pilot study of human papillomavirus (HPV) self-sampling among non-attenders was performed, aiming to assess three different screening approaches. Participants and methods Non-attenders aged 30-64 years from two Slovenian regions were randomised to two HPV self-sampling groups-the opt-in (I1, n = 14.400) and the opt-out (I2, n = 9.
View Article and Find Full Text PDFBackground: Primary soft tissue sarcomas of the breast are extremely rare neoplasms, and the value of a fine needle aspiration biopsy (FNAB) in the preoperative or intraoperative diagnosis of soft tissue tumors in the breast is still controversial. Nevertheless, correct recognition of such lesions can avoid unnecessary sentinel and axillary lymph node dissection.
Case: We report a 45-year-old woman who presented with a 10-cm tumor in her right breast.
Aims: to determine correlations between relative quantities of telomerase catalytic subunit m-ribonucleic acid (hTERT mRNA) and conventional clinicopathological parameters (such as site, size and grade of tumour, the presence of regional lymph node metastases, and, in particular, survival) in patients with laryngeal and hypopharyngeal squamous cell carcinomas (SCCs).
Material And Methods: The relative quantity of hTERT mRNA was analysed by a commercially available LightCycler Telo TAGGG hTERT Quantification Kit in 56 cases of SCC (40 laryngeal and 16 hypopharyngeal). The association with cancer-specific survival was evaluated by univariate and multivariate analysis.
Background/aims: The influence of end-stage kidney failure on the progression of liver disease in patients infected with hepatitis C virus and treated with hemodialysis is still controversial.
Methodology: Liver histology of 154 hepatitis C virus infected non-uremic patients was compared with liver histology of 13 hepatitis C virus infected uremic patients treated with hemodialysis.
Results: In either group of altogether 167 patients, no normal liver histology was found.