The influence of muscle performance and fatigue on prognosis in patients with compensated liver disease.

Background: Poor muscle function is associated with a negative prognosis in advanced liver disease but the impact in compensated chronic liver disease is unknown. Similar prognostic uncertainty applies to fatigue. We aimed to assess the prognostic value of muscle performance and fatigue in a cohort of patients with compensated chronic liver disease.

Muscle performance and fatigue in compensated chronic liver disease.

A common and debilitating symptom in patients with chronic liver disease is fatigue (CLD). Muscle dysfunction has been suggested to be a key mechanism of fatigue in CLD. We aimed to evaluate fatigue and the potential association with muscle performance and physical activity in outpatients with CLD.